ArticleNature chemistry2022
Visible light-driven conjunctive olefination.
Article in Nature chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Photocatalytic Radical Functionalization of Alkenylammonium Salts.Precision chemistry · 2026Article
- Stereoselective additions to alkenylphosphonium salts for the synthesis of P-stereogenic compounds.Chemical science · 2026Article
- Photocatalytic deoxygenative Z-selective olefination of aliphatic alcohols.Nature communications · 2025Article
- Bifunctional iron-catalyzed alkyne Z-selective hydroalkylation and tandem Z-E inversion via radical molding and flipping.Nature communications · 2024Article
- Carbonyl cross-metathesis via deoxygenative gem-di-metal catalysis.Nature chemistry · 2024Article
- Programmable synthesis of difluorinated hydrocarbons from alkenes through a photocatalytic linchpin strategy.Chemical science · 2023Article
- Polarity Transduction Enables the Formal Electronically Mismatched Radical Addition to Alkenes.Journal of the American Chemical Society · 2023Article
- Enantio- andScience advances · 2023Article
- Modular allylation of C(spChemical science · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carboxylic acids and aldehydes are ubiquitous in chemistry and are native functionalities in many bioactive molecules and natural products. As such, a general cross-coupling process that involves these partners would open new avenues to achieve molecular diversity. Here we report a visible-light-mediated and transition metal-free conjunctive olefination that uses an alkene 'linchpin' with a defined geometry to cross-couple complex molecular scaffolds that contain carboxylic acids and aldehydes. The chemistry merges two cornerstones of organic synthesis-namely, the Wittig reaction and photoredox catalysis-in a catalytic cycle that couples a radical addition process with the redox generation of a phosphonium ylide. The methodology allows the rapid structural diversification of bioactive molecules and natural products in a native form, with a high functional group tolerance, and also forges a new alkene functional group with a programmable E-Z stereochemistry.
Identifiers
34737455What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.