ArticleNature methods2021
Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography.
Article in Nature methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it, 298 citations in OpenAlex.
- Vasculature segmentation in 3D hierarchical phase-contrast tomography images of human kidneys.Nature communications · 2026Pooled it
- Differential aperture modulation enables high-fidelity 3D photoacoustic imaging.Photoacoustics · 2026Article
- Finite element modeling of human Achilles tendon: impact of subtendon modeling and fiber direction.Biomechanics and modeling in mechanobiology · 2026Article
- Next-generation kidney tissue analysis - spatial omics and digital pathology.Nature reviews. Nephrology · 2026Review
- Supersampled Scanning Transmission X-Ray Microscopy for High-Resolution Vibration-Independent Time-Resolved Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- The functional impact of myofiber macroscopic organization and disarray in computational models of the murine heart.PLoS computational biology · 2026Article
- Fast eikonal phase retrieval for high-throughput beamlines.Journal of synchrotron radiation · 2026Article
- Crystallography in Open Science and its open educational resources.Acta crystallographica. Section A, Foundations and advances · 2026Article
- Evolution of hierarchical phase-contrast tomography on the European Synchrotron beamlines BM05 and BM18: a whole adult human brain imaging case study.Journal of synchrotron radiation · 2026Article
- The heterogeneous nature of atrioventricular conduction tissues in tetralogy of Fallot demonstrated by hierarchical phase-contrast tomography.JTCVS structural and endovascular · 2026Article
- Directional dark field for nanoscale full-field transmission X-ray microscopy.Light, science & applications · 2026Article
- Neutron and photon science facilities at a crossroads: embracing innovation in a changing world.IUCrJ · 2026Article
- Multimodal techniques based on synchrotron radiation X-rays for revealing interactions of metallic nanoparticles with biological matrices.Fundamental research · 2026Review
- Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- High-throughput, organ-scale 3D tubule tracking using TubuleMAP.Research square · 2026Article
- High-throughput, organ-scale 3D tubule tracking using TubuleMAP.bioRxiv : the preprint server for biology · 2026Article
- Bridging the microstructural gap in human connectomics using hierarchical phase-contrast tomography as a reference for diffusion MRI in the human brain.bioRxiv : the preprint server for biology · 2026Article
- VesSynth: Tubes Are All You Need for Robust Cross-Scale Cross-Modal 3D Vessel Segmentation.bioRxiv : the preprint server for biology · 2026Article
- Quantitative Stain Mapping in X-Ray Virtual Histology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Three-dimensional high-content imaging of unstained soft tissue with subcellular resolution using a laboratory-based X-ray microscope.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
18 authors at 10 institutions in 3 countries.
Funding
Abstract
Imaging intact human organs from the organ to the cellular scale in three dimensions is a goal of biomedical imaging. To meet this challenge, we developed hierarchical phase-contrast tomography (HiP-CT), an X-ray phase propagation technique using the European Synchrotron Radiation Facility (ESRF)'s Extremely Brilliant Source (EBS). The spatial coherence of the ESRF-EBS combined with our beamline equipment, sample preparation and scanning developments enabled us to perform non-destructive, three-dimensional (3D) scans with hierarchically increasing resolution at any location in whole human organs. We applied HiP-CT to image five intact human organ types: brain, lung, heart, kidney and spleen. HiP-CT provided a structural overview of each whole organ followed by multiple higher-resolution volumes of interest, capturing organotypic functional units and certain individual specialized cells within intact human organs. We demonstrate the potential applications of HiP-CT through quantification and morphometry of glomeruli in an intact human kidney and identification of regional changes in the tissue architecture in a lung from a deceased donor with coronavirus disease 2019 (COVID-19).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.