ArticleNature genetics2021
Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues.
Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 74 citations in OpenAlex.
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- tugMedi: simulator of cancer-cell evolution for personalized medicine based on the genomic data of patients.NPJ systems biology and applications · 2026Article
- Synonymous substitutions confer the conservedHorticulture research · 2026Article
- Modeling the evolutionary dynamics of clonal hematopoiesis.Nature genetics · 2026Review
- Segregating DNA lesions point to high selective advantage of tumor initiating cells.bioRxiv : the preprint server for biology · 2025Article
- Review
- Clonal Hematopoiesis in Cancer and Cardiovascular Disease: JACC: CardioOncology State-of-the-Art Review.JACC. CardioOncology · 2025Review
- Single-cell mutational burden distributions in birth-death processes.PLoS computational biology · 2025Article
- Detecting and quantifying clonal selection in somatic stem cells.Nature genetics · 2025Article
- Contributions of Noncardiac Organ-Heart Immune Crosstalk and Somatic Mosaicism to Heart Failure: Current Knowledge and Perspectives.Circulation research · 2025Review
- Article
- Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution.Cell genomics · 2025Article
- Age-related cardiovascular disease and mosaic hematopoietic loss of the Y chromosome.The journal of cardiovascular aging · 2025Article
- Competition for resources can reshape the evolutionary properties of spatial structure.PLoS computational biology · 2024Article
- The emergence of clonal hematopoiesis as a disease determinant.The Journal of clinical investigation · 2024Article
- Clonal dynamics and somatic evolution of haematopoiesis in mouse.bioRxiv : the preprint server for biology · 2024Article
- Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis.Nature communications · 2024Article
- Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis.Nature genetics · 2024Article
- Cell of origin epigenetic priming determines susceptibility to Tet2 mutation.Nature communications · 2024Article
- Effects of lifestyle factors on leukocytes in cardiovascular health and disease.Nature reviews. Cardiology · 2024Review
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4 authors at 2 institutions in 2 countries.
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Abstract
Genetic alterations under positive selection in healthy tissues have implications for cancer risk. However, total levels of positive selection across the genome remain unknown. Passenger mutations are influenced by all driver mutations, regardless of type or location in the genome. Therefore, the total number of passengers can be used to estimate the total number of drivers-including unidentified drivers outside of cancer genes that are traditionally missed. Here we analyze the variant allele frequency spectrum of synonymous mutations from healthy blood and esophagus to quantify levels of missing positive selection. In blood, we find that only 30% of passengers can be explained by single-nucleotide variants in driver genes, suggesting high levels of positive selection for mutations elsewhere in the genome. In contrast, more than half of all passengers in the esophagus can be explained by just the two driver genes NOTCH1 and TP53, suggesting little positive selection elsewhere.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.