ArticleNature communications2021
A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- The Laryngeal Auditory Startle Reflex (LASR): A New Component of the Auditory Startle Response.The Laryngoscope · 2026Article
- Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia.Science advances · 2026Article
- Region-specific microglial alterations in the acoustic startle circuit in Shank3 mice.Biochemistry and biophysics reports · 2026Article
- The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson's disease male mice.NPJ Parkinson's disease · 2026Article
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- A multicellular analysis calcium imaging toolbox for ImageJ.Cell reports methods · 2026Article
- Spinal glycine receptor alpha 1 coordinates startle behavior through a cell-type specific mechanism.International journal of biological sciences · 2026Article
- The activation of catecholamine neurons in the rostral ventrolateral medulla drives ventricular remodeling after myocardial ischemia/reperfusion injury.Basic research in cardiology · 2025Article
- Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention.Progress in neurobiology · 2025Review
- High throughput machine learning pipeline to characterize larval zebrafish motor behavior.PloS one · 2025Article
- Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits.Acta neuropathologica communications · 2024Article
- From innate to instructed: A new look at perceptual decision-making.Current opinion in neurobiology · 2024Review
- Advances in neural circuits of innate fear defense behavior.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Nucleus reticularis tegmenti pontis: a bridge between the basal ganglia and cerebellum for movement control.Experimental brain research · 2023Article
- Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders.Frontiers in behavioral neuroscience · 2023Review
- A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions.Molecular psychiatry · 2022Article
- Identification of a Glutamatergic Claustrum-Anterior Cingulate Cortex Circuit for Visceral Pain Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reticulotegmental nucleus (RtTg) has long been recognized as a crucial component of brainstem reticular formation (RF). However, the function of RtTg and its related circuits remain elusive. Here, we report a role of the RtTg in startle reflex, a highly conserved innate defensive behaviour. Optogenetic activation of RtTg neurons evokes robust startle responses in mice. The glutamatergic neurons in the RtTg are significantly activated during acoustic startle reflexes (ASR). Chemogenetic inhibition of the RtTg glutamatergic neurons decreases the ASR amplitudes. Viral tracing reveals an ASR neural circuit that the cochlear nucleus carrying auditory information sends direct excitatory innervations to the RtTg glutamatergic neurons, which in turn project to spinal motor neurons. Together, our findings describe a functional role of RtTg and its related neural circuit in startle reflexes, and demonstrate how the RF connects auditory system with motor functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.