ArticleNature communications2021
Photo-induced copper-catalyzed sequential 1,n-HAT enabling the formation of cyclobutanols.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 34 citations in OpenAlex.
- Cobalt-Catalyzed γ‑C-H Functionalization of Alcohols via Olefin-Tethered Radical Relay.JACS Au · 2026Article
- Site-Selective C─H Bond Functionalization of Sugars.Angewandte Chemie (International ed. in English) · 2025Article
- Biomimetic Catalytic Remote Desaturation of Aliphatic Alcohols.Organic letters · 2025Article
- Paired Electrolysis Enables Reductive Heck Coupling of Unactivated (Hetero)Aryl Halides and Alkenes.Angewandte Chemie (International ed. in English) · 2024Article
- Azetidine synthesis enabled by photo-induced copper catalysis via [3+1] radical cascade cyclization.Innovation (Cambridge (Mass.)) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cyclobutanols are privileged cyclic skeletons in natural products and synthetic building blocks. C(sp3)-H functionalization is a prolonged challenge in organic synthesis. The synthesis of cyclobutanols through double C(sp3)-H bond functionalization remains elusive. Here we report the efficient synthesis of cyclobutanols through intermolecular radical [3 + 1] cascade cyclization, involving the functionalization of two C - H bonds through sequential hydrogen atom transfer. The copper complex reduces the iodomethylsilyl alcohols efficiently under blue-light irradiation to initiate the tandem transformation. The mild reaction tolerates a broad range of functional groups and allows for the facile generation of elaborate polycyclic structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.