Evidence map›Paper›PMID 34737316›Full record

ArticleNature communications2021

Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands.

N'Toia C Hawkins, James L Kizziah, José R Penadés, Terje Dokland

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Capsid redirection mechanism of thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  5. Genetics, ecology and evolution of phage satellites.Nature reviews. Microbiology · 2025
    Review
  6. Article
  7. AeLife · 2024
    Article
  8. Article
  9. AbioRxiv : the preprint server for biology · 2023
    Article
  10. Article
  11. Structure and host specificity ofScience advances · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

N'Toia C HawkinsDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
James L KizziahDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-2608-8595
José R PenadésCenter for Molecular Bacteriology and Infection, Imperial College London, London, UK.ORCID 0000-0002-6439-5262
Terje DoklandDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA. dokland@uab.edu.ORCID 0000-0001-5655-4123
University of Alabama at Birmingham · USImperial College London · GB

Funding

Structural basis for pathogenicity island mobilization in S. aureusR01AI083255 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOKLAND, TERJE · 2009 to 2023
$5.6M
The Southeastern Consortium for Microscopy of MacroMolecular MachinesU24GM116788 · NIGMS · FLORIDA STATE UNIVERSITY · PI AGBANDJE-MCKENNA, MAVIS, BULLITT, ESTHER · 2016 to 2020
$4.6M
Novel mechanism of cos phage size redirection by staphylococcal pathogenicity islandsR21AI132977 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOKLAND, TERJE · 2017 to 2018
$408k
NIAID NIH HHS R01 AI083255NIAID NIH HHS R21 AI132977NIGMS NIH HHS U24 GM116788
6 · The paper itself

Abstract

Staphylococcus aureus pathogenicity islands (SaPIs) are molecular parasites that hijack helper phages for their transfer. SaPIbov5, the prototypical member of a family of cos type SaPIs, redirects the assembly of ϕ12 helper capsids from prolate to isometric. This size and shape shift is dependent on the SaPIbov5-encoded protein Ccm, a homolog of the ϕ12 capsid protein (CP). Using cryo-electron microscopy, we have determined structures of prolate ϕ12 procapsids and isometric SaPIbov5 procapsids. ϕ12 procapsids have icosahedral end caps with T

Indexed as

CapsidCapsid ProteinsGenomic IslandsStaphylococcusCapsid Proteins

Identifiers

PMID34737316
PMCPMC8569155
OpenAlexW3210545527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.