ArticleNature communications2021
Sensory-motor cortices shape functional connectivity dynamics in the human brain.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 116 citations in OpenAlex.
- Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- From localized to long-range: functional connectivity alterations in mild to moderate chronic low back pain patients.Quantitative imaging in medicine and surgery · 2026Article
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Tract-explainable and underexplained synchrony play complementary roles in the functional organization of the brain.bioRxiv : the preprint server for biology · 2026Article
- A Deep Learning Framework for Spatiotemporal Modeling of Visual Task fMRI.bioRxiv : the preprint server for biology · 2026Article
- Resting-state EEG alpha-BOLD coupling spatially follows cortical cell-type and receptor gradients.bioRxiv : the preprint server for biology · 2026Article
- Normative Modeling of Static and Dynamic Functional Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Temporal synchrony and spatial similarity of interbrain subnetworks predict dyadic social interaction.Communications biology · 2026Article
- The role of connectivity for the degeneracy of the brain's resting state dynamics.Journal of computational neuroscience · 2026Article
- A deformable attractor manifold organizes human resting-state brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Artificial intelligence as a surrogate brain: bridging neural dynamical models and data.National science review · 2026Review
- Article
- Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics.PLoS computational biology · 2025Article
- cuBNM: GPU-Accelerated Brain Network Modeling.bioRxiv : the preprint server for biology · 2025Article
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Modeling macroscopic brain dynamics with brain-inspired computing architecture.Nature communications · 2025Article
- Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms.eLife · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
Large-scale biophysical circuit models provide mechanistic insights into the micro-scale and macro-scale properties of brain organization that shape complex patterns of spontaneous brain activity. We developed a spatially heterogeneous large-scale dynamical circuit model that allowed for variation in local synaptic properties across the human cortex. Here we show that parameterizing local circuit properties with both anatomical and functional gradients generates more realistic static and dynamic resting-state functional connectivity (FC). Furthermore, empirical and simulated FC dynamics demonstrates remarkably similar sharp transitions in FC patterns, suggesting the existence of multiple attractors. Time-varying regional fMRI amplitude may track multi-stability in FC dynamics. Causal manipulation of the large-scale circuit model suggests that sensory-motor regions are a driver of FC dynamics. Finally, the spatial distribution of sensory-motor drivers matches the principal gradient of gene expression that encompasses certain interneuron classes, suggesting that heterogeneity in excitation-inhibition balance might shape multi-stability in FC dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.