ArticleNature communications2021
Computational optical sectioning with an incoherent multiscale scattering model for light-field microscopy.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Rapid robust high-fidelity 3D neuronal extraction from multiview calcium imaging datasets.Nature methods · 2026Article
- Real-time robust autofocus method enabling sustained intravital scanning light field imaging.Nature communications · 2026Article
- Foveated light-field compound imager.Science advances · 2026Article
- High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics.Nature biotechnology · 2026Article
- Foveated Light-Field Compound Imager.bioRxiv : the preprint server for biology · 2026Article
- Intravital mesoscale optical imaging: challenges, techniques, and future perspectives.Biophysics reports · 2026Article
- Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Leveraging spatial-angular redundancy for self-supervised denoising of 3D fluorescence imaging without temporal dependency.Nature communications · 2025Article
- Kilohertz volumetric imaging of in vivo dynamics using squeezed light field microscopy.Nature methods · 2025Article
- Physics-driven self-supervised learning for fast high-resolution robust 3D reconstruction of light-field microscopy.Nature methods · 2025Article
- Advancing Multicolor Super-Resolution Volume Imaging: Illuminating Complex Cellular Dynamics.JACS Au · 2025Review
- Dark-based optical sectioning assists background removal in fluorescence microscopy.Nature methods · 2025Article
- Fluorescence microscopy through scattering media with robust matrix factorization.Cell reports methods · 2025Article
- Multiscale and recursive unmixing of spatiotemporal rhythms for live-cell and intravital cardiac microscopy.Nature cardiovascular research · 2025Article
- Long-term intravital subcellular imaging with confocal scanning light-field microscopy.Nature biotechnology · 2025Article
- Increasing the spatial bandwidth product in light field microscopy with remote scanning.Biomedical optics express · 2025Article
- Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.Neurophotonics · 2025Review
- Ultra-fast light-field microscopy with event detection.Light, science & applications · 2024Article
- Efficient high-resolution fluorescence projection imaging over an extended depth of field through optical hardware and deep learning optimizations.Biomedical optics express · 2024Article
- Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution.Nature biomedical engineering · 2024Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative volumetric fluorescence imaging at high speed across a long term is vital to understand various cellular and subcellular behaviors in living organisms. Light-field microscopy provides a compact computational solution by imaging the entire volume in a tomographic way, while facing severe degradation in scattering tissue or densely-labelled samples. To address this problem, we propose an incoherent multiscale scattering model in a complete space for quantitative 3D reconstruction in complicated environments, which is called computational optical sectioning. Without the requirement of any hardware modifications, our method can be generally applied to different light-field schemes with reduction in background fluorescence, reconstruction artifacts, and computational costs, facilitating more practical applications of LFM in a broad community. We validate the superior performance by imaging various biological dynamics in Drosophila embryos, zebrafish larvae, and mice.
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