ArticleNature communications2021
MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
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- Machine Learning-Optimized Single-Atom Catalysts Enable Microenvironment-Adaptive Chemodynamic-Bioorthogonal Cancer Therapy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Emerging Nanoreactors for Precision Disease Treatment: From Principles to Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Mitochondria-Targeted MPDA Nanosystem Co-Delivering Evodiamine and IR820 for Chemo-Photothermal Therapy of Hepatocellular Carcinoma.International journal of nanomedicine · 2026Article
- Nanomaterial-Mediated Targeting of Mitochondrial Metabolism: Strategies and Applications in Cancer Therapy.International journal of nanomedicine · 2026Review
- Recent advances of metal-organic frameworks (MOFs) for drug delivery, cancer imaging and theranostics.Theranostics · 2026Review
- Acidogenesis-Propelled Coordination Transition in Light-Triggered Fe-Polyphenol Polymer for Reactive Oxygen Species-Augmented Antitumor Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanism of glycolysis-pyrolysis crosstalk driving vicious circle of intervertebral disc degeneration.Apoptosis : an international journal on programmed cell death · 2025Article
- Ion-interference amplifier nano-system enhances radiotherapy via mitochondrial dysfunction and efferocytosis Inhibition.Journal of nanobiotechnology · 2025Article
- MitoSiege-Driven Catalase Collapse: A GSH-Responsive, Mitochondria-Targeted COF Prodrug for Amplified Chemodynamic Therapy.Angewandte Chemie (International ed. in English) · 2025Article
- A Metal-Peptide Framework as a Nanozyme for the Attenuation of Amyloid‑β Aggregation and Reactive Oxygen Species.JACS Au · 2025Article
- Concave-Octahedral FeGels (Basel, Switzerland) · 2025Article
- Nanotherapeutic strategies exploiting biological traits of cancer stem cells.Bioactive materials · 2025Review
- Dysregulation of Mitochondrial Function in Cancer Cells.International journal of molecular sciences · 2025Review
- Recent advances and applications of mitochondria in tumors and inflammation.Journal of translational medicine · 2025Review
- A tandem-unlocked cascade nanoreactor for high-contrast magnetic resonance imaging-guided enhanced ferroptosis-chemo synergistic therapy.Materials today. Bio · 2025Article
- A Nanotherapeutic Agent for Synergistic Tumor Therapy: Co-Activation of Photochemical-Biological Effects.Angewandte Chemie (International ed. in English) · 2025Article
- Living Microalgae-Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy.Advanced healthcare materials · 2025Article
- Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy.Materials today. Bio · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeting subcellular organelle with multilevel damage has shown great promise for antitumor therapy. Here, we report a core-shell type of nanoagent with iron (III) carboxylate metal-organic frameworks (MOFs) as shell while upconversion nanoparticles (UCNPs) as core, which enables near-infrared (NIR) light-triggered synergistically reinforced oxidative stress and calcium overload to mitochondria. The folate decoration on MOFs shells enables efficient cellular uptake of nanoagents. Based on the upconversion ability of UCNPs, NIR light mediates Fe
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