Evidence map›Paper›PMID 34737264›Full record

ArticleLight, science & applications2021

Color Cherenkov imaging of clinical radiation therapy.

Daniel A Alexander, Anthony Nomezine, Lesley A Jarvis, David J Gladstone, Brian W Pogue, Petr Bruza

Abstract read
In one paragraph

Article in Light, science & applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Hybrid Monte Carlo model for efficient tissue Cherenkov emission estimation to assess changes from beam size, energy and incidence.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Imaging and characterization of optical emission fromPhysics in medicine and biology · 2024
    Article
  12. Interfacial Cherenkov radiation from ultralow-energy electrons.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel A Alexander *Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0003-3831-7479
Anthony Nomezine *Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Lesley A JarvisGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, NH, USA. Petr.Bruza@dartmouth.edu.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
DoseRT™ : A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy VerificationR44CA232879 · NCI · DOSEOPTICS, LLC · PI William Ware · 2018 to 2026
$5.2M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA232879NIBIB NIH HHS R01 EB023909U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5P30 CA023108-41
6 · The paper itself

Abstract

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and major vessels within the body.

Identifiers

PMID34737264
PMCPMC8569159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.