ArticleProceedings of the National Academy of Sciences of the United States of America2021
Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 77 citations in OpenAlex.
- Development of a high-throughput screening platform for identification of functional BACH1 inhibitors reveals compounds with anti-invasive potential.Redox biology · 2026Article
- Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.Antioxidants (Basel, Switzerland) · 2026Review
- Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice.Alzheimer's research & therapy · 2026Article
- A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.Redox biology · 2026Article
- Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases.Acta pharmaceutica Sinica. B · 2026Review
- Single-cell atlas of the developing Down syndrome brain cortex.Nature medicine · 2026Article
- Sources of Oxidative Stress in Parkinson's Disease: Pathways and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2026Review
- Transcranial direct current stimulation exerts neuroprotective effects in Parkinson's disease by restoring Mlst8-mediated autophagic homeostasis.Journal of translational medicine · 2026Article
- Targeting BACH1 by HPPE inhibits the Wnt/β-catenin pathway and malignant phenotype in glioblastoma cells.Apoptosis : an international journal on programmed cell death · 2025Article
- A BACH1 inhibitor ameliorates myocardial infarction and limb ischemia in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Neuronutrition and Nrf2 Brain Resilience Signaling: Epigenomics and Metabolomics for Personalized Medicine in Nervous System Disorders from Bench to Clinic.International journal of molecular sciences · 2025Review
- p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.Acta pharmacologica Sinica · 2025Article
- Prominin-2/FBXO22/BACH1 axis protects bone marrow mesenchymal stem cells against TBHP-induced ferroptosis and ameliorates intervertebral disc degeneration.Stem cell research & therapy · 2025Article
- BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NADMolecular medicine (Cambridge, Mass.) · 2025Article
- Ferrocene-derived magnetic fiber-particles from diesel exhaust: enhanced pulmonary toxicity via Bach1-SAT1-polyamine depletion.Journal of nanobiotechnology · 2025Article
- Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis.Nature communications · 2025Article
- Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis.Journal of translational medicine · 2025Article
- The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- HPPE Activates NRF2 Signaling by Liberating Heavy Metal Stores.Chembiochem : a European journal of chemical biology · 2025Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
16 authors at 7 institutions in 3 countries.
Manuj AhujaDarby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425.
Navneet Ammal KaideryDarby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425.
Otis C AttucksvTv Therapeutics LLC, High Point, NC 27265.
Erin McDadevTv Therapeutics LLC, High Point, NC 27265.
Dmitry M HushpulianFaculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 109028, Russia.ORCID 0000-0002-2171-9896
Arsen GaisinIntegrated Molecular Structure Education and Research Center, Northwestern University, IL 60208.
Irina GaisinaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL 60612.ORCID 0000-0002-8668-3222
Young Hoon AhnDepartment of Chemistry, Wayne State University, Detroit, MI 48202.ORCID 0000-0003-0765-3074
Sergey NikulinFaculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 109028, Russia.
Andrey PoloznikovFaculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 109028, Russia.ORCID 0000-0003-1816-8699
Irina GazaryanFaculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 109028, Russia.
Masayuki YamamotoDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Mitsuyo MatsumotoDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.ORCID 0000-0002-2918-9893
Kazuhiko IgarashiDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.ORCID 0000-0002-2470-2475
Sudarshana M SharmaDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425.
Bobby ThomasDarby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425; thomasbo@musc.edu.ORCID 0000-0001-9244-9726
Medical University of South Carolina · USNational Research University Higher School of Economics · RUTohoku University · JPvTv Therapeutics (United States) · USNorthwestern University · USUniversity of Illinois Urbana-Champaign · USWayne State University · US
Funding
Role of Bach-1-Mediated Transcriptional Regulation in NeuroprotectionR01NS101967 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI THOMAS, BOBBY · 2017 to 2021
$1.9MOrbitrap Fusion Lumos ETD Mass SpectrometerS10OD025126 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BALL, LAUREN ELIZABETH · 2018 to 2018
$991kNIH HHS S10 OD025126NINDS NIH HHS R01 NS101967
Abstract
PubMed holds no abstract for this paper.
Indexed as
Neuroprotection1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAgedAged, 80 and overAnimalsAntioxidant Response ElementsBasic-Leucine Zipper Transcription FactorsCase-Control StudiesDisease Models, AnimalDrug Evaluation, PreclinicalFemaleHumansMaleMiceMice, KnockoutParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineBACH1 protein, humanBasic-Leucine Zipper Transcription FactorsBach1MPTPNrf2Parkinson’s diseasetranscriptional repressor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.