Evidence map›Paper›PMID 34737152›Full record

ArticleEnvironment international2022

Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry.

Douglas I Walker, Jaime E Hart, Chirag J Patel, Ruthann Rudel, Jen-Hwa Chu, Eric Garshick, Kurt D Pennell, Francine Laden, Dean P Jones

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.Journal of occupational medicine and toxicology (London, England) · 2024
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Douglas I WalkerDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: douglas.walker@mssm.edu.
Jaime E HartChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Chirag J PatelDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, United States.
Ruthann RudelSilent Spring Institute, Newton, MA, United States.
Jen-Hwa ChuPulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.
Eric GarshickChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Pulmonary, Allergy, Sleep and Critical Care Medicine, VA Boston Healthcare System, Boston, MA, United States.
Kurt D PennellSchool of Engineering, Brown University, Providence, RI, United States.
Francine LadenChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Dean P JonesClinical Biomarkers Laboratory, Department of Medicine, Emory University, Atlanta, GA, United States.
Harvard University · USBrigham and Women's Hospital · USBrown University · USEmory University · USIcahn School of Medicine at Mount Sinai · USSilent Spring Institute · USYale University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
DIESEL PARTICLE EXPOSURE AND LUNG CANCERR01CA090792 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARSHICK, ERIC · 2001 to 2005
$4.8M
BIOMARKERS OF EXPOSURE AND EFFECT IN A TRAFFIC EXPOSED POPULATIONR01ES016284 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI LADEN, FRANCINE · 2008 to 2011
$2.8M
Orbitrap Elite/H-ESI BundleS10OD018006 · OD · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2014 to 2014
$600k
Mitochondria Environmental Stress Signaling NetworksR21ES025632 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2015 to 2017
$576k
Blood Markers of Mobile Source Particle ExposureR21ES013726 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI GARSHICK, ERIC · 2006 to 2007
$472k
NCI NIH HHS R01 CA090792NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES016284NIEHS NIH HHS R21 ES013726NIEHS NIH HHS R21 ES025632NIEHS NIH HHS T32 ES007069NIH HHS S10 OD018006
6 · The paper itself

Abstract

Exposure to traffic-related pollutants, including diesel exhaust, is associated with increased risk of cardiopulmonary disease and mortality; however, the precise biochemical pathways underlying these effects are not known. To investigate biological response mechanisms underlying exposure to traffic related pollutants, we used an integrated molecular response approach that included high-resolution metabolomic profiling and peripheral blood gene expression to identify biological responses to diesel exhaust exposure. Plasma samples were collected from 73 non-smoking males employed in the US trucking industry between February 2009 and October 2010, and analyzed using untargeted high-resolution metabolomics to characterize metabolite associations with shift- and week-averaged levels of elemental carbon (EC), organic carbon (OC) and particulate matter with diameter ≤ 2.5 μm (PM

Indexed as

Air PollutantsAir PollutionTraffic-Related PollutionHumansMaleParticulate MatterVehicle EmissionsAir PollutantsParticulate MatterVehicle EmissionsDiesel exhaustExposomicsHigh-resolution mass spectrometryMetabolomicsMulti-omicsTraffic-related pollutants

Identifiers

PMID34737152
PMCPMC9624233
OpenAlexW3209028250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.