Evidence map›Paper›PMID 34736951›Full record

ArticleAmerican journal of ophthalmology2022

Ocular Biometric Determinants of Dark-to-Light Change in Angle Width: The Chinese American Eye Study.

Jacob Lifton, Bruce Burkemper, Xuejuan Jiang, Anmol A Pardeshi, Grace Richter, Roberta McKean-Cowdin, Rohit Varma, Benjamin Y Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jacob LiftonFrom the Keck School of Medicine (J.L.), at the University of Southern California, Los Angeles, California, USA.
Bruce BurkemperUSC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Xuejuan JiangUSC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Anmol A PardeshiUSC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Grace RichterUSC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Roberta McKean-CowdinUSC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA; Department of Preventive Medicine (R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Rohit VarmaSouthern California Eye Institute (R.V.), CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA.
Benjamin Y XuFrom the Keck School of Medicine (J.L.), at the University of Southern California, Los Angeles, California, USA; USC Roski Eye Institute, Department of Ophthalmology (B.B., X.J., A.A.P., G.R., R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA; Department of Preventive Medicine (R.M.-C.), Keck School of Medicine at the University of Southern California, Los Angeles, California, USA; Southern California Eye Institute (R.V.), CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA. Electronic address: benjamin.xu@med.usc.edu.
University of Southern California · USPenn Presbyterian Medical Center · US

Funding

Chinese American Eye StudyU10EY017337 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 2009 to 2013
$10.2M
Development and Validation of Quantitative Anterior Segment OCT-based Methods to Evaluate Patients with Primary Angle Closure DiseaseK23EY029763 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI XU, BENJAMIN Y. · 2019 to 2023
$1.1M
NEI NIH HHS K23 EY029763NEI NIH HHS U10 EY017337
6 · The paper itself

Abstract

purposeTo assess ocular biometric determinants of dark-to-light change in anterior chamber angle width and identify dynamic risk factors in primary angle closure disease (PACD).

designPopulation-based cross-sectional study.

methodsChinese American Eye Study (CHES) participants underwent anterior segment optical coherence tomography imaging in the dark and light. Static dark and light biometric parameters, including angle opening distance, 750 µm (AOD750), anterior chamber width (ACW), lens vault (LV), and pupillary diameter (PD) were measured, and dynamic dark-to-light changes were calculated. Contributions by static and dynamic parameters to dark-to-light changes in AOD750 were assessed using multivariable linear regression models with standardized regression coefficients (SRCs) and semipartial correlation coefficients squared (SPCC

resultsThe analysis included 1011 participants. All biometric parameters differed between dark and light (P < .05). On multivariable regression analysis, change in ACW (SRC = -0.35, SPCC

conclusionsBeneficial angle widening effects of transitioning from dark to light are attenuated in eyes with PACD, which appears related to aberrant dark-to-light change in ACW. These findings highlight the importance of assessing the angle in both dark and light to identify potential dynamic mechanisms of angle closure.

Indexed as

Glaucoma, Angle-ClosureAnterior Eye SegmentAsianCross-Sectional StudiesGonioscopyHumansIntraocular PressureTomography, Optical Coherence

Identifiers

PMID34736951
PMCPMC9035021
OpenAlexW3210651978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.