ArticleExperimental eye research2021
Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.
Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Characterizing Initial Cervical Spine and Neurovascular Findings in 84 Consecutive Patients with Hypermobile Ehlers-Danlos Syndrome: A Retrospective Study.Journal of clinical medicine · 2026Article
- An automated optical coherence tomography to finite element analysis pipeline reveals key morphological determinants of optic nerve head biomechanics in glaucoma.Eye (London, England) · 2026Article
- AstroOphthalmology: Basic and Pathophysiological Concepts of Space-Induced Ocular Changes.Eye and brain · 2026Review
- Lamina cribrosa shape in non-human primates is different from that of humans.Experimental eye research · 2025Article
- Cervical Oculopathy: The Cervical Spine Etiology of Visual Symptoms and Eye Diseases-A Hypothesis Exploring Mechanisms Linking the Neck and the Eye.Diagnostics (Basel, Switzerland) · 2025Article
- Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.Investigative ophthalmology & visual science · 2025Article
- Deformation Response of the Human Lamina Cribrosa to Intracranial Pressure Lowering.Journal of biomechanical engineering · 2025Article
- Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering.Journal of biomechanical engineering · 2025Article
- Clinical implications of real-time optic nerve sheath diameter assessment via critical care ultrasound in intracranial hypertension.Frontiers in neurology · 2025Article
- Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels.bioRxiv : the preprint server for biology · 2024Article
- Precisional modulation of translaminar pressure gradients for ophthalmic diseases.European journal of ophthalmology · 2024Review
- Optic Nerve Head Changes Measured by Swept Source Optical Coherence Tomography and Angiography in Patients with Intracranial Hypertension.Ophthalmology and therapy · 2023Article
- Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model.The ocular surface · 2023Article
- Predatory Bacteria can ReducebioRxiv : the preprint server for biology · 2023Article
- Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension.Investigative ophthalmology & visual science · 2023Article
- Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications.Frontiers in ophthalmology · 2023Article
- Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem.Translational vision science & technology · 2022Article
- Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues.Investigative ophthalmology & visual science · 2022Article
- Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa.Experimental eye research · 2022Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Intracranial pressure (ICP) has been proposed to play an important role in the sensitivity to intraocular pressure (IOP) and susceptibility to glaucoma. However, the in vivo effects of simultaneous, controlled, acute variations in ICP and IOP have not been directly measured. We quantified the deformations of the anterior lamina cribrosa (ALC) and scleral canal at Bruch's membrane opening (BMO) under acute elevation of IOP and/or ICP. Four eyes of three adult monkeys were imaged in vivo with OCT under four pressure conditions: IOP and ICP either at baseline or elevated. The BMO and ALC were reconstructed from manual delineations. From these, we determined canal area at the BMO (BMO area), BMO aspect ratio and planarity, and ALC median depth relative to the BMO plane. To better account for the pressure effects on the imaging, we also measured ALC visibility as a percent of the BMO area. Further, ALC depths were analyzed only in regions where the ALC was visible in all pressure conditions. Bootstrap sampling was used to obtain mean estimates and confidence intervals, which were then used to test for significant effects of IOP and ICP, independently and in interaction. Response to pressure manipulation was highly individualized between eyes, with significant changes detected in a majority of the parameters. Significant interactions between ICP and IOP occurred in all measures, except ALC visibility. On average, ICP elevation expanded BMO area by 0.17 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.