Evidence map›Paper›PMID 34736808›Full record

ReviewSeminars in fetal & neonatal medicine2021

Neuroimaging in the term newborn with neonatal encephalopathy.

Jessica L Wisnowski, Pia Wintermark, Sonia L Bonifacio, Christopher D Smyser, A James Barkovich, A David Edwards, Linda S de Vries, Terrie E Inder, Vann Chau, Newborn Brain Society Guidelines and Publications Committee

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. MRI scoring systems in neonatal encephalopathy and neurodevelopmental outcomes: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 4 countries.

Jessica L WisnowskiDepartments of Radiology and Pediatrics (Neonatology), Children's Hospital Los Angeles, 4650 Sunset Blvd. MS #81, Los Angeles CA 90027, USA. Electronic address: wisnowsk@usc.edu.
Pia WintermarkDepartment of Pediatrics (Neonatology), McGill University/Montreal Children's Hospital, Division of Newborn Medicine, Research Institute of the McGill University Health Centre, 1001 boul. Décarie, Site Glen Block E, EM0.3244, Montréal, QC H4A 3J1, Canada. Electronic address: pia.wintermark@gmail.com.
Sonia L BonifacioDivision of Neonatal and Developmental Medicine, Department of Pediatrics (Neonatology), Lucile Packard Children's Hospital, Stanford University School of Medicine, 750 Welch Road, Suite 315, Palo Alto, CA 94304, USA. Electronic address: soniab1@stanford.edu.
Christopher D SmyserDepartments of Neurology, Radiology, and Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO 63110-1093, USA. Electronic address: smyserc@wustl.edu.
A James BarkovichDepartment of Radiology, UCSF Benioff Children's Hospital, University of California San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143-0628, USA. Electronic address: james.barkovich@ucsf.edu.
A David EdwardsEvelina London Children's Hospital, Centre for Developing Brain, King's College London, Westminster Bridge Road, London, SE1 7EH, United Kingdom. Electronic address: ad.edwards@kcl.ac.uk.
Linda S de VriesDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Lundlaan 6, 3584 EA, Utrecht, the Netherlands. Electronic address: l.s.devries@umcutrecht.nl.
Terrie E InderDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tinder@bwh.harvard.edu.
Vann ChauDepartment of Pediatrics (Neurology), The Hospital for Sick Children, University of Toronto, 555 University Avenue, Room 6513, Toronto, ON M5G 1X8, Canada. Electronic address: vann.chau@sickkids.ca.
Newborn Brain Society Guidelines and Publications Committee
Children's Hospital of Los Angeles · USEvelina London Children's Healthcare · GBHarvard University · USHospital for Sick Children · CAMcGill University Health Centre · CAStanford University · USUCSF Benioff Children's Hospital · USUniversity Medical Center Utrecht · NLWashington University in St. Louis · US

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
CIHRMedical Research Council G0801320NICHD NIH HHS K23 HD099309NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Last, recommendations for neuroimaging in neonates with NE are presented.

Indexed as

Brain InjuriesHypoxia-Ischemia, BrainInfant, Newborn, DiseasesHumansInfant, NewbornMagnetic Resonance ImagingNeuroimagingAdvanced MRI techniquesAsphyxiaDiffusion-tensor imagingDiffusion-weighted imagingHypoxic-ischemic brain injuryMagnetic resonance spectroscopy imagingNeonatal encephalopathyNeonatesOutcome predictionPredictive values

Identifiers

PMID34736808
PMCPMC9135955
OpenAlexW3210948071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.