Evidence map›Paper›PMID 34736509›Full record

Trial reportTrials2021

Update to a randomized controlled trial of lutetium-177-PSMA in Oligo-metastatic hormone-sensitive prostate cancer: the BULLSEYE trial.

Bastiaan M Privé, Marcel J R Janssen, Inge M van Oort, Constantijn H J Muselaers, Marianne A Jonker, Willemijn A van Gemert, Michel de Groot, Harm Westdorp, Niven Mehra, J Fred Verzijlbergen and 13 more

Registry-linked trialOpen access · goldAbstract readLetterMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443062 (Lutetium-177-PSMA-617 Radioligand Therapy in Oligo-metastatic Hormone Sensitive Prostate Cancer.), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04443062 phase2completednot on this map

Lutetium-177-PSMA-617 Radioligand Therapy in Oligo-metastatic Hormone Sensitive Prostate Cancer.

TypeinterventionalSponsorRadboud University Medical CenterRan2020 to 2026Enrolled58ConditionsProstate CancerArms177Lu-PSMA-617
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. [PSMA radioligand therapy-State of the art].Urologie (Heidelberg, Germany) · 2025
    Review
  7. The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer.European journal of nuclear medicine and molecular imaging · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Novel radionuclide therapy combinations in prostate cancer.Therapeutic advances in medical oncology · 2023
    Review
  17. Article
  18. Review
  19. Oligometastatic Prostate Cancer: Current Status and Future Challenges.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Bastiaan M PrivéDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4056-9117
Marcel J R JanssenDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Inge M van OortDepartment of Urology, Radboudumc, Nijmegen, The Netherlands.
Constantijn H J MuselaersDepartment of Urology, Radboudumc, Nijmegen, The Netherlands.
Marianne A JonkerDepartment of Health Evidence, Radboudumc, Nijmegen, The Netherlands.
Willemijn A van GemertDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Michel de GrootDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Harm WestdorpDepartment of Medical Oncology, Radboudumc, Nijmegen, The Netherlands.
Niven MehraDepartment of Medical Oncology, Radboudumc, Nijmegen, The Netherlands.
J Fred VerzijlbergenDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Tom W J ScheenenDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Patrik ZámecnikDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Jelle O BarentszDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Martin GotthardtDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
Walter NoordzijDepartment of Radiology and Nuclear Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wouter V VogelDepartment of Radiology and Nuclear Medicine, NKI Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Andries M BergmanDepartment of Medical Oncology, NKI Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Henk G van der PoelDepartment of Urology, NKI Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
André N VisDepartment of Urology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Daniela E Oprea-LagerDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Winald R GerritsenDepartment of Medical Oncology, Radboudumc, Nijmegen, The Netherlands.
J Alfred WitjesDepartment of Urology, Radboudumc, Nijmegen, The Netherlands.
James NagarajahDepartment of Radiology and Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands. james.nagarajah@radboudumc.nl.
Radboud University Nijmegen · NLThe Netherlands Cancer Institute · NLAmsterdam University Medical Centers · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe BULLSEYE trial is a multicenter, open-label, randomized controlled trial to test the hypothesis if CHANGES IN METHODS AND MATERIALS: Two important changes were made to the original protocol: (1) the study will now use

conclusionsWe present an update of the original study protocol prior to the completion of the study. Treatment arm patients that were included and received

trial registrationClinicalTrials.gov NCT04443062 . First posted: June 23, 2020.

Indexed as

Androgen AntagonistsProstatic Neoplasms, Castration-ResistantHormonesHumansLutetiumMaleRadioisotopesAndrogen AntagonistsHormonesLutetiumLutetium-177RadioisotopesHormone-sensitive prostate cancerLutetium-177-PSMAMetastases-directed therapyOligometastasesRadioligand therapyUrologic oncology

Identifiers

PMID34736509
PMCPMC8566967
OpenAlexW3208276018

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.