Evidence map›Paper›PMID 34736497›Full record

ArticleTrials2021

REDUCE trial: the effects of perineural dexamethasone on scalp nerve blocks for relief of postcraniotomy pain-a study protocol for a randomized controlled trial.

Chunmei Zhao, Zipu Jia, Niti Shrestha, Fang Luo

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04648358 (REDUCE Trial), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04648358 nacompletednot on this map

REDUCE Trial: The Effects of Perineural Dexamethasone on Scalp Nerve Blocks for Relief of Postcraniotomy Pain

TypeinterventionalSponsorBeijing Tiantan HospitalRan2020 to 2023Enrolled156ConditionsPostoperative Pain, Craniotomy, Dexamethasone, Scalp Nerve BlocksArmsBupivacaine, Dexamethasone combined with bupivacaine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chunmei Zhao *Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zipu Jia *Department of Day Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Niti Shrestha *Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Fang LuoDepartment of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. 13611326978@163.com.ORCID http://orcid.org/0000-0002-3584-0355
Capital Medical University · CN

Funding

Capital's Funds for Health Improvement and Research No. 2020-2-2046
6 · The paper itself

Abstract

backgroundPain is common in the first 2 days after major craniotomy. Inadequate analgesia may lead to an increased risk of postoperative complications. Most pain following craniotomy arises from the pericranial muscles and soft tissues of the scalp. Scalp nerve blocks with local anesthesia seem to provide effective, safe, however, transient postoperative analgesia which does not seem to meet the requirements of craniotomy. Currently, peripheral dexamethasone has been observed to significantly prolong the duration of analgesia of nerve blocks (e.g., saphenous nerve block, adductor canal block, thoracic paravertebral block, brachial plexus nerve block). On the contrary, a study reported that perineural dexamethasone did not appear to prolong the analgesic time after supratentorial craniotomy. However, all patients in this study were given 24 mg of oral or intravenous dexamethasone regularly for at least 7 days during the perioperative period, which possibly masked the role of single local low doses of perineural dexamethasone. Therefore, the analgesic effect of single dexamethasone for scalp nerve blocks without the background of perioperative glucocorticoid deserves further clarification.

methodsThe REDUCE trial is a prospective, single-center, parallel-group randomized controlled trial involving a total of 156 adults scheduled for elective craniotomy with general anesthesia. Patients will be randomly divided among two groups: the control group (n = 78) will receive scalp nerve blocks with 0.5% bupivacaine, plus normal saline with epinephrine at 1:200,000; the DEX DISCUSSION: The REDUCE trial aims to further assess the analgesic effect of single dexamethasone as an adjuvant to scalp nerve blocks for relief of postcraniotomy pain without the background of perioperative glucocorticoid.

trial registrationClinicalTrials.gov NCT04648358 . Registered on November 30, 2020.

Indexed as

Brachial Plexus BlockScalpAdultAnesthetics, LocalDexamethasoneDouble-Blind MethodHumansPostoperative PainProspective StudiesRandomized Controlled Trials as TopicAnesthetics, LocalDexamethasoneCraniotomyDexamethasonePostoperative painRandomized controlled trialScalp nerve blocks

Identifiers

PMID34736497
PMCPMC8567555
OpenAlexW3209797089

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.