Evidence map›Paper›PMID 34736475›Full record

SynthesisBMC medicine2021

The dose-response relationship between socioeconomic deprivation and alcohol-attributable mortality risk-a systematic review and meta-analysis.

Charlotte Probst, Shannon Lange, Carolin Kilian, Celine Saul, Jürgen Rehm

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05865847 (Unveiling the Alcohol Harm Paradox), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05865847 unknown statusnot on this map

Unveiling the Alcohol Harm Paradox: Analysis of Socioeconomic Differences in Alcohol Harm in Finland in a Nationwide Cohort Study

TypeobservationalSponsorFinnish Institute for Health and WelfareRan2015 to 2023Enrolled3,950,000ConditionsAlcohol-Related DisordersArmsNot applicable, this is an observational study
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Employment Status and Alcohol-Attributable Mortality Risk-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Do socioeconomic status, race and ethnicity modify the relationship between alcohol use and unintentional injury mortality?Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Charlotte ProbstInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), Toronto, ON, M5S 2S1, Canada. mariecharlotte.probst@gmail.com.ORCID 0000-0003-4360-697X
Shannon LangeInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), Toronto, ON, M5S 2S1, Canada.
Carolin KilianInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, 01187, Dresden, Germany.
Celine SaulHeidelberg Institute of Global Health (HIGH), Medical Faculty and University Hospital, Heidelberg University, 69120, Heidelberg, Germany.
Jürgen RehmInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), Toronto, ON, M5S 2S1, Canada.
Centre for Addiction and Mental Health · CAHeidelberg University · DETechnische Universität Dresden · DE

Funding

Supplement to a microsimulation of alcohol control interventions to advance health equity and reverse the current decrease in life expectancy in the USR01AA028009 · NIAAA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI PROBST, CHARLOTTE · 2020 to 2024
$2.4M
NIAAA NIH HHS R01 AA028009
6 · The paper itself

Abstract

backgroundIndividuals with low socioeconomic status (SES) experience a higher risk of mortality, in general, and alcohol-attributable mortality in particular. However, a knowledge gap exists concerning the dose-response relationships between the level of socioeconomic deprivation and the alcohol-attributable mortality risk.

methodsWe conducted a systematic literature search in August of 2020 to update a previous systematic review that included studies published up until February of 2013. Quantitative studies reporting on socioeconomic inequality in alcohol-attributable mortality among the general adult population were included. We used random-effects dose-response meta-analyses to investigate the relationship between the level of socioeconomic deprivation and the relative alcohol-attributable risk (RR), by sex and indicator of SES (education, income, and occupation).

resultsWe identified 25 eligible studies, comprising about 241 million women and 230 million men, among whom there were about 75,200 and 308,400 alcohol-attributable deaths, respectively. A dose-response relationship between the level of socioeconomic deprivation and the RR was found for all indicators of SES. The sharpest and non-linear increase in the RR of dying from an alcohol-attributable cause of death with increasing levels of socioeconomic deprivation was observed for education, where, compared to the most educated individuals, individuals at percentiles with decreasing education had the following RR of dying: women: 25th: 2.09 [95% CI 1.70-2.59], 50th: 3.43 [2.67-4.49], 75th: 4.43 [3.62-5.50], 100th: 4.50 [3.26-6.40]; men: 25th: 2.34 [1.98-2.76], 50th: 4.22 [3.38-5.24], 75th: 5.87 [4.75-7.10], 100th: 6.28 [4.89-8.07].

conclusionsThe findings of this study show that individuals along the entire continuum of SES are exposed to increased alcohol-attributable mortality risk. Differences in the dose-response relationship can guide priorities in targeting public health initiatives.

Indexed as

IncomeAdultFemaleHumansMaleRisk FactorsSocioeconomic FactorsAlcohol useDose-responseInequalityMortalityPublic healthSocioeconomic deprivationSocioeconomic status

Identifiers

PMID34736475
PMCPMC8569998
OpenAlexW3208561325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.