Evidence map›Paper›PMID 34736425›Full record

SynthesisBMC public health2021

Individual and poly-substance use and condomless sex among HIV-uninfected adults reporting heterosexual sex in a multi-site cohort.

R J Fredericksen, B M Whitney, E Trejo, R M Nance, E Fitzsimmons, F L Altice, A W Carrico, C M Cleland, C Del Rio, A Duerr and 14 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 16 institutions in 2 countries.

R J FredericksenUW Center for AIDS Research, Harborview Medical Center, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104-2499, USA. rfrederi@uw.edu.ORCID 0000-0003-3936-7048
B M WhitneyUW Center for AIDS Research, Harborview Medical Center, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104-2499, USA.
E TrejoUW Center for AIDS Research, Harborview Medical Center, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104-2499, USA.
R M NanceUW Center for AIDS Research, Harborview Medical Center, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104-2499, USA.
E FitzsimmonsUW Center for AIDS Research, Harborview Medical Center, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104-2499, USA.
F L AlticeYale University AIDS Program, 135 College Street, Suite 323, New Haven, CT, 06510-2283, USA.
A W CarricoDivision of Prevention Science and Community Health, University of Miami, 1120 NW 14th St, Miami, FL, 33136, USA.
C M ClelandCenter for Drug Use and HIV Research, NYU School of Global Public Health, 665 Broadway, 11th Floor, New York, NY, 10012, USA.
C Del RioRollins School of Public Health, Emory University, 1518 Clifton Road, NE Room 7011, Atlanta, GA, 30322, USA.
A DuerrFred Hutchinson Cancer Research Center, HIV Vaccine Trials Network, Box 358080 (LE 500), Seattle, WA, 98109, USA.
W M El-SadrMailman School of Public Health, Columbia University, 722 West 168th Street, 13th floor, New York, NY, 10032, USA.
S KahanaNational Institute on Drug Abuse, 6001 Executive Blvd, Rockville, Maryland, 20852, USA.
I KuoDepartment of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave NW #2, Washington, DC, 20052, USA.
K MayerThe Fenway Institute, 1340 Boylston Street, Boston, MA, 02215, USA.
S MehtaJohns Hopkins University, Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Maryland, 21205, USA.
L J OuelletSchool of Public Health, University of Illinois at Chicago, 1603 W. Taylor St, Chicago, IL, USA.
V M QuanDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland, 21205, USA.
J RichCenter for Prisoner Health and Human Rights, Immunology Center, The Miriam Hospital, Warren Alpert Medical School, Brown University, 1125 North Main St, Providence, RI, 02904, USA.
D W SealDepartment of Global Community Health and Behavioral Sciences, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St, Suite 2200, New Orleans, LA, 70112, USA.
S SpringerDepartment of Internal Medicine, School of Medicine, Yale University, 135 College Street, New Haven, CT, 06510, USA.
F TaxmanCenter for Advancing Correctional Excellence, Institute of Biohealth Innovation, George Mason University, 4461 Rockfish Creek Lane, Fairfax, VA, 22030, USA.
W WechsbergDepartment of Health Policy and Management, Gillings School of Public Health, University of North Carolina Chapel Hill, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.
H M CraneUW Center for AIDS Research, Harborview Medical Center, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104-2499, USA.
J A C DelaneyCollege of Pharmacy, University of Manitoba, Apotex Centre, 750 McDermot Avenue, Winnipeg, Manitoba, R3E 0T5, Canada.
Harborview Medical Center · USJohns Hopkins University · USYale University · USBrown University · USColumbia University · USEmory University · USFenway Health · USFred Hutch Cancer Center · USGeorge Mason University · USMilken Institute · USNational Institute on Drug Abuse · USTulane University · USUniversity of Illinois Chicago · USUniversity of Manitoba · CAUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Peer-driven Intervention to Seek, Test & Treat Heterosexuals at High Risk for HIVR01DA032083 · NIDA · NEW YORK UNIVERSITY · PI GWADZ, MARYA · 2011 to 2015
$7.5M
Seek, Test, Treat: An Integrated Jail-Prison-Community Model for IllinoisR01DA030796 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI OUELLET, LAWRENCE J, PUISIS, MICHAEL · 2010 to 2015
$5.5M
Naltrexone for Opioid Dependent Released HIV+ Criminal Justice PopulationsR01DA030762 · NIDA · YALE UNIVERSITY · PI SPRINGER, SANDRA ANN · 2010 to 2015
$4.1M
Seek, Test, Treat & Retain Pilot for Out of School Teens at RiskR01DA032061 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI WECHSBERG, WENDEE M · 2011 to 2015
$4.0M
Seek, Test, Treat, and Retain Data Harmonization Coordinating CenterU01DA037702 · NIDA · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., DELANEY, JOSEPH AUSTIN · 2014 to 2019
$3.8M
A Randomized Controlled Trial and Cohort Study of HIV Testing and Linkage to CareR01DA030771 · NIDA · FRIENDS RESEARCH INSTITUTE, INC. · PI GORDON, MICHAEL SCOTT, RICH, JOSIAH D · 2010 to 2015
$3.3M
STAR-Seek, Test and Retain. Linkages for Black HIV+, Substance Using MSMR01DA032100 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EL-SADR, WAFAA M., MANNHEIMER, SHARON B · 2011 to 2015
$2.7M
Medication Assisted Therapy as a Conduit to Care for HIV+ CJS Populations TransitK02DA032322 · NIDA · YALE UNIVERSITY · PI SPRINGER, SANDRA ANN · 2011 to 2022
$1.3M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS BRIGHT1 R01DA030771NIDA NIH HHS K02 DA032322NIDA NIH HHS R01 DA030762NIDA NIH HHS R01 DA030771NIDA NIH HHS R01 DA030796NIDA NIH HHS R01 DA032061NIDA NIH HHS R01 DA032083NIDA NIH HHS R01 DA032100NIDA NIH HHS STAR R01DA032100NIDA NIH HHS STTS R01DA030796NIDA NIH HHS U01 DA037702NIDA NIH HHS U01DA037702
6 · The paper itself

Abstract

backgroundWe analyzed the association between substance use (SU) and condomless sex (CS) among HIV-negative adults reporting heterosexual sex in the Seek, Test, Treat, and Retain (STTR) consortium. We describe the impact of SU as well as person/partner and context-related factors on CS, identifying combinations of factors that indicate the highest likelihood of CS.

methodsWe analyzed data from four US-based STTR studies to examine the effect of SU on CS using two SU exposures: 1) recent SU (within 3 months) and 2) SU before/during sex. Behavioral data were collected via 1:1 or self-administered computerized interviews. Adjusted individual-study, multivariable relative risk regression was used to examine the relationship between CS and SU. We also examined interactions with type of sex and partner HIV status. Pooled effect estimates were calculated using traditional fixed-effects meta-analysis. We analyzed data for recent SU (n = 6781; 82% men, median age = 33 years) and SU before/during sex (n = 2915; 69% men, median age = 40 years).

resultsFor both exposure classifications, any SU other than cannabis increased the likelihood of CS relative to non-SU (8-16%, p-values< 0.001). In the recent SU group, however, polysubstance use did not increase the likelihood of CS compared to single-substance use. Cannabis use did not increase the likelihood of CS, regardless of frequency of use. Type of sex was associated with CS; those reporting vaginal and anal sex had a higher likelihood of CS compared to vaginal sex only for both exposure classifications (18-21%, p < 0.001). Recent SU increased likelihood of CS among those reporting vaginal sex only (9-10%, p < 0.001); results were similar for those reporting vaginal and anal sex (5-8%, p < 0.01). SU before/during sex increased the likelihood of CS among those reporting vaginal sex only (20%; p < 0.001) and among those reporting vaginal and anal sex (7%; p = 0.002). Single- and poly-SU before/during sex increased the likelihood of CS for those with exclusively HIV-negative partners (7-8%, p ≤ 0.02), and for those reporting HIV-negative and HIV-status unknown partners (9-13%, p ≤ 0.03).

conclusionExcept for cannabis, any SU increased the likelihood of CS. CS was associated with having perceived HIV-negative partners and with having had both anal/vaginal sex.

Indexed as

HIV InfectionsSubstance-Related DisordersAdultCondomsFemaleHeterosexualityHomosexuality, MaleHumansMaleRisk-TakingSexual BehaviorSexual PartnersUnsafe SexCondom useSubstance use

Identifiers

PMID34736425
PMCPMC8567631
OpenAlexW3110898807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.