Evidence map›Paper›PMID 34736396›Full record

ArticleBMC geriatrics2021

Compromised intestinal integrity in older adults during daily activities: a pilot study.

Sharon Hendriks, Suzanne C Stokmans, Matthijs Plas, Wim A Buurman, Sophie L W Spoorenberg, Klaske Wynia, Erik Heineman, Barbara L van Leeuwen, Jacco J de Haan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sharon Hendriks *Department of Surgery, University Medical Center Groningen, 9713, GZ, Groningen, The Netherlands. s.hendriks@umcg.nl.ORCID 0000-0002-7551-1599
Suzanne C Stokmans *Department of Surgery, University Medical Center Groningen, 9713, GZ, Groningen, The Netherlands.
Matthijs PlasDepartment of Surgery, University Medical Center Groningen, 9713, GZ, Groningen, The Netherlands.
Wim A BuurmanMHeNs School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
Sophie L W SpoorenbergDepartment of Health Sciences, Community and Occupational Medicine, University Medical Center Groningen, Groningen, The Netherlands.
Klaske Wynia *Department of Health Sciences, Community and Occupational Medicine, University Medical Center Groningen, Groningen, The Netherlands.
Erik HeinemanDepartment of Surgery, University Medical Center Groningen, 9713, GZ, Groningen, The Netherlands.
Barbara L van LeeuwenDepartment of Surgery, University Medical Center Groningen, 9713, GZ, Groningen, The Netherlands.
Jacco J de HaanDepartment of Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalnutrition is a common and significant problem in older adults. Insight into factors underlying malnutrition is needed to develop strategies that can improve the nutritional status. Compromised intestinal integrity caused by gut wall hypoperfusion due to atherosclerosis of the mesenteric arteries in the aging gastrointestinal tract may adversely affect nutrient uptake. The presence of compromised intestinal integrity in older adults is not known. The aim of this study is to provide a proof-of-concept that intestinal integrity is compromised in older adults during daily activities.

methodsAdults aged ≥75 years living independently without previous gastrointestinal disease or abdominal surgery were asked to complete a standardized walking test and to consume a standardized meal directly afterwards to challenge the mesenteric blood flow. Intestinal fatty acid-binding protein (I-FABP) was measured as a plasma marker of intestinal integrity, in blood samples collected before (baseline) and after the walking test, directly after the meal, and every 15 min thereafter to 75 min postprandially.

resultsThirty-four participants (median age 81 years; 56% female) were included. Of the participants, 18% were malnourished (PG-SGA score ≥ 4), and 32% were at risk of malnutrition (PG-SGA score, 2 or 3). An I-FABP increase of ≥50% from baseline was considered a meaningful loss of intestinal integrity and was observed in 12 participants (35%; 8 females; median age 80 years). No significant differences were observed in either baseline characteristics, walking test scores, or calorie/macronutrient intake between the groups with and without a ≥ 50% I-FABP peak.

conclusionThis study is first to indicate that intestinal integrity is compromised during daily activities in a considerable part of older adults living independently.

Indexed as

MalnutritionAgedAged, 80 and overAgingEnergy IntakeFemaleHumansMaleNutritional StatusPilot ProjectsIntestinal integrityMalnutritionMesenteric ischemiaNutritionOlder adults

Identifiers

PMID34736396
PMCPMC8567646
OpenAlexW3210991894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.