Evidence map›Paper›PMID 34736365›Full record

ArticleEmerging microbes & infections2021

Colistin-phage combinations decrease antibiotic resistance in

Xiaoqing Wang, Belinda Loh, Fernando Gordillo Altamirano, Yunsong Yu, Xiaoting Hua, Sebastian Leptihn

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 104 citations in OpenAlex.

  1. Engineering the probioticSynthetic and systems biotechnology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Synergy antibacterial effects of lytic phage vB_AbaA_LLY and levofloxacin against KL2 and KL160 Acinetobacter baumannii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Antimicrobial agents and chemotherapy · 2026
    Article
  16. Advances in phage therapy forFrontiers in microbiology · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 5 countries.

Xiaoqing WangZhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, People's Republic of China.
Belinda LohDepartment of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, People's Republic of China.ORCID 0000-0003-1364-6911
Fernando Gordillo AltamiranoSchool of Biological Sciences, Monash University, Clayton, Australia.ORCID 0000-0002-4581-1259
Yunsong YuDepartment of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.ORCID 0000-0003-2903-918X
Xiaoting HuaDepartment of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.ORCID 0000-0001-8215-916X
Sebastian LeptihnZhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, People's Republic of China.ORCID 0000-0002-4847-4622
Sir Run Run Shaw Hospital · CNImpact · CALishui University · CNXi’an Jiaotong-Liverpool University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant bacterial infections are becoming increasingly common, with only few last-resort antibiotics such as colistin available for clinical therapy. An alternative therapeutic strategy gaining momentum is phage therapy, which has the advantage of not being affected by bacterial resistance to antibiotics. However, a major challenge in phage therapy is the rapid emergence of phage-resistant bacteria. In this work, our main aim was to understand the mechanisms of phage-resistance used by the top priority pathogen

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsBacteriophagesColistinDrug Resistance, BacterialHumansMicrobial Sensitivity TestsWhole Genome SequencingAnti-Bacterial AgentsColistinantibiotic resensitationcolistin resistancePhagephage adsorptionphage-resistancephage therapyvirulence

Identifiers

PMID34736365
PMCPMC8648044
OpenAlexW3209519038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.