Evidence map›Paper›PMID 34736157›Full record

ArticleParkinsonism & related disorders2021

Neuropsychological outcomes after thalamic deep brain stimulation for essential tremor.

Kaltra Dhima, Julia Biars, Efstathios Kondylis, Sean Nagel, Xin Xin Yu, Darlene P Floden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kaltra DhimaDepartment of Neurology, Cleveland Clinic, Cleveland, OH, USA.
Julia BiarsCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA.
Efstathios KondylisDepartment of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA.
Sean NagelCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA; Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA.
Xin Xin YuDepartment of Neurology, Cleveland Clinic, Cleveland, OH, USA; Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA.
Darlene P FlodenDepartment of Neurology, Cleveland Clinic, Cleveland, OH, USA; Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA. Electronic address: flodend@ccf.org.

Funding

Neurophysiology of response inhibition in PDK23NS091344 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FLODEN, DARLENE · 2015 to 2019
$843k
NINDS NIH HHS K23 NS091344
6 · The paper itself

Abstract

introductionNon-motor DBS outcomes have received little attention in ET relative to PD. This study examines neuropsychological outcomes in ET following thalamic VIM DBS.

methodsFifty patients completed neuropsychological evaluations preoperatively and approximately seven months postoperatively. Cognition and mood changes were analyzed at the group level and individual level. Additional associations with treatment, disease, and demographic characteristics were assessed.

resultsSignificant cognitive decline was not observed at the group level. At the individual level, 46% of patients demonstrated at least subtle overall cognitive decline (≥1SD on at least one test within at least two domains). Mild decline (≥1SD) was seen in 10%-29.17% of patients on individual tests across all cognitive domains, with highest rates in verbal memory. Substantial cognitive decline (≥2SD) occurred in less than 9% of the sample across all tests. Factors related to cognitive decline included higher DBS parameter settings, older age of ET onset, intracranial complications, and inability to reduce ET medications postoperatively. Depression and anxiety did not change when accounting for questionnaire items that could be falsely elevated by tremor.

conclusionSubstantial cognitive decline after VIM DBS is rare in patients with ET. However, subtle decrements can occur across cognitive domains and particularly in verbal memory. DBS parameter settings may relate to cognitive decline. Further research is needed to better understand possible associations with electrode lateralization and other variables that could also relate to disease progression and test-retest effects. Symptoms of depression and anxiety remain stable.

Indexed as

AffectAgedCognitionCognitive DysfunctionDeep Brain StimulationEssential TremorFemaleHumansMaleMemoryNeuropsychological TestsPostoperative Cognitive ComplicationsPostoperative PeriodRetrospective StudiesThalamusTreatment OutcomeCognitionDeep brain stimulationEssential tremorMoodNeuropsychological outcomes

Identifiers

PMID34736157
PMCPMC8633186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.