Evidence map›Paper›PMID 34735924›Full record

ArticleImmunobiology2021

Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.

Eric Yau, Yan Chen, Chunhua Song, Jason Webb, Marykate Carillo, Yuka Imamura Kawasawa, Zhenyuan Tang, Yoshinori Takahashi, Todd M Umstead, Sinisa Dovat and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Disruption of the SP-A/SP-R210American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Eric YauDepartment of Pediatrics and Microbiology and Immunology, Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, PA, USA. Electronic address: eyau@pennstatehealth.psu.edu.
Yan ChenDepartment of Pediatrics and Microbiology and Immunology, Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, PA, USA; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chunhua SongDepartment of Pediatrics, Division of Pediatric Hematology and Oncology, Pennsylvania State University College of Medicine, PA, USA; Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA.
Jason WebbDepartment of Pediatrics and Microbiology and Immunology, Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, PA, USA.
Marykate CarilloDepartment of Pediatrics and Microbiology and Immunology, Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, PA, USA.
Yuka Imamura KawasawaDepartment of Pharmacology and Biochemistry and Molecular Biology, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, PA, USA.
Zhenyuan TangDepartment of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yoshinori TakahashiDepartment of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Todd M UmsteadDepartment of Pediatrics and Microbiology and Immunology, Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, PA, USA.
Sinisa DovatDepartment of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zissis C ChroneosDepartment of Pediatrics and Microbiology and Immunology, Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, PA, USA. Electronic address: zchroneos@pennstatehealth.psu.edu.
Pennsylvania State University · USUnion Hospital · CN

Funding

Regulation of the lung antiviral inflammatory responseR56HL128746 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHRONEOS, ZISSIS C · 2015 to 2015
$387k
NHLBI NIH HHS R56 HL128746
6 · The paper itself

Abstract

Macrophages play an important role in maintaining tissue homeostasis, from regulating the inflammatory response to pathogens to resolving inflammation and aiding tissue repair. The surfactant protein A (SP-A) receptor SP-R210 (MYO18A) has been shown to affect basal and inflammatory macrophage states. Specifically, disruption of the longer splice isoform SP-R210

Indexed as

Adaptation, BiologicalAnimalsBiomarkersCell LineDisease SusceptibilityEpigenomicsGenomicsHost-Pathogen InteractionsImmunophenotypingMacrophagesMiceMyosinsProtein IsoformsRAW 264.7 CellsSignal TransductionBiomarkersMYO18A protein, humanMyosinsProtein IsoformsAnti-viral inflammationInfluenzaMacrophage phenotype and functionPU.1 SP-R210 (Myo18A) isoforms

Identifiers

PMID34735924
PMCPMC8863115
OpenAlexW3208312923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.