Evidence map›Paper›PMID 34735839›Full record

ArticleJournal of psychiatric research2021

Longitudinal relationship between maternal distress and pediatric mood symptoms in youth with mood disorders.

Marc J Weintraub, Christopher D Schneck, Manpreet K Singh, Patricia D Walshaw, Kiki D Chang, Aimee E Sullivan, David J Miklowitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Relations among symptoms of depression over time in at-risk youth.Journal of psychopathology and clinical science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Marc J WeintraubSemel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA. Electronic address: mjweintraub@mednet.ucla.edu.
Christopher D SchneckUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Manpreet K SinghStanford University School of Medicine, Palo Alto, CA, USA.
Patricia D WalshawSemel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Kiki D ChangPrivate Practice, Menlo Park, CA, USA.
Aimee E SullivanUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
David J MiklowitzSemel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of Colorado Anschutz Medical Campus · USMenlo School · USPalo Alto University · USUniversity of California, Santa Barbara · US

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
2/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093666 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO · 2012 to 2016
$2.0M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
App-Enhanced CBT for Adolescents at High Risk for Severe Mood DisordersK23MH124015 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEINTRAUB, MARC JOSHUA · 2021 to 2024
$779k
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
NIMH NIH HHS K23 MH124015NIMH NIH HHS R01 MH093666NIMH NIH HHS R01 MH093676NIMH NIH HHS R01 MH123575NIMH NIH HHS R34 MH077856NIMH NIH HHS R34 MH117200NIMH NIH HHS R37 MH085953
6 · The paper itself

Abstract

Parents of a child with a mood disorder report significant levels of distress and burden from caregiving. This study examined whether maternal distress varies over time with levels of mood symptoms in youth with mood disorders, and whether expressed emotion (EE) and family functioning moderate these associations. We recruited youth (ages 9-17 years) with mood disorders and familial risk for bipolar disorder (BD) for a randomized trial of family-focused therapy compared to standard psychoeducation. Participants were assessed every 4-6 months for up to 4 years. Using repeated-measures mixed effects modeling, we examined the longitudinal effects of youths' mood symptoms and maternal distress concurrently, as well as whether each variable predicted the other in successive study intervals. Secondary analyses examined the moderating effects of EE and ratings of family cohesion and adaptability on maternal distress. In sample of 118 youth-mother dyads, levels of self-reported parental distress decreased over time, with no differences between treatment conditions. Youths' depressive symptoms and, most strongly, mood lability were associated with greater maternal distress longitudinally; however, maternal distress did not predict youths' mood symptoms or lability. The effect of youth symptoms on maternal distress was greater among mothers who were high EE. Family cohesion was associated with reduced concurrent ratings of maternal distress, whereas family adaptability was associated with reduced maternal distress at successive follow-ups. While maternal distress decreases over time as youths' symptoms decrease, mothers of youth with mood disorders experience significant distress that is directly linked to the youths' depressive symptom severity and lability. Improved family functioning appears to be an important mechanism by which to intervene.

Indexed as

Bipolar DisorderMood DisordersAdolescentAffectChildFamily TherapyFemaleHumansMothersBurdenDepressionExpressed emotionFamily functioningMood lability

Identifiers

PMID34735839
PMCPMC8667659
OpenAlexW3208956892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.