Evidence map›Paper›PMID 34735799›Full record

ReviewThe Lancet. Infectious diseases2022

Medical countermeasures against henipaviruses: a review and public health perspective.

Raúl Gómez Román, Nadia Tornieporth, Neil George Cherian, Amy C Shurtleff, Maïna L'Azou Jackson, Debra Yeskey, Adam Hacker, Eric Mungai, Tung Thanh Le

Open access · bronzeAbstract readReview
In one paragraph

Review in The Lancet. Infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. One health (Amsterdam, Netherlands) · 2026
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  20. Single-dose intranasal AdC68-vectored vaccines rapidly protect Syrian hamsters against lethal Nipah virus infection.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Raúl Gómez RománCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Nadia TornieporthCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway; University of Applied Sciences & Arts, Hanover, Germany.
Neil George CherianCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Amy C ShurtleffCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Maïna L'Azou JacksonCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Debra YeskeyCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Adam HackerCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Eric MungaiCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway.
Tung Thanh LeCoalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway. Electronic address: tung.le@cepi.net.
Coalition for Epidemic Preparedness Innovations · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Henipaviruses, including Nipah virus, are regarded as pathogens of notable epidemic potential because of their high pathogenicity and the paucity of specific medical countermeasures to control infections in humans. We review the evidence of medical countermeasures against henipaviruses and project their cost in a post-COVID-19 era. Given the sporadic and unpredictable nature of henipavirus outbreaks, innovative strategies will be needed to circumvent the infeasibility of traditional phase 3 clinical trial regulatory pathways. Stronger partnerships with scientific institutions and regulatory authorities in low-income and middle-income countries can inform coordination of appropriate investments and development of strategies and normative guidelines for the deployment and equitable use of multiple medical countermeasures. Accessible measures should include global, regional, and endemic in-country stockpiles of reasonably priced small molecules, monoclonal antibodies, and vaccines as part of a combined collection of products that could help to control henipavirus outbreaks and prevent future pandemics.

Indexed as

Medical CountermeasuresPublic HealthAnimalsChiropteraClinical Trials, Phase III as TopicCOVID-19Disease OutbreaksHenipavirusHenipavirus InfectionsHumansNipah Virus

Identifiers

PMID34735799
PMCPMC8694750
OpenAlexW3209489543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.