Evidence map›Paper›PMID 34735776›Full record

Trial reportAmerican journal of respiratory and critical care medicine2022

Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF).

Helge Hebestreit, Susi Kriemler, Christian Schindler, Lothar Stein, Chantal Karila, Don S Urquhart, David M Orenstein, Larry C Lands, Jonathan Schaeff, Ernst Eber and 2 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. The 2025 European Cystic Fibrosis Society position statement on physical activity assessment in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Guideline
  2. Physical activity and exercise training in cystic fibrosis.The Cochrane database of systematic reviews · 2022
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Helge HebestreitPaediatric Department, University Hospitals Würzburg, Würzburg, Germany.
Susi KriemlerEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Christian SchindlerSwiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
Lothar SteinInstitute of Sports Medicine, Hannover Medical School, Hannover, Germany.
Chantal KarilaService de Pneumologie et Allergologie Pédiatriques, AP-HP Hôpital Necker Enfants Malades, Université Paris Descartes, Paris, France.
Don S UrquhartDepartment of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Sick Children, Edinburgh, United Kingdom.
David M OrensteinDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Larry C LandsMontreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; and.
Jonathan SchaeffPaediatric Department, University Hospitals Würzburg, Würzburg, Germany.
Ernst EberDivision of Paediatric Pulmonology and Allergology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Thomas RadtkeEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
ACTIVATE-CF Study Working Group
Universitätsklinikum Würzburg · DEUniversity of Zurich · CHChildren's Hospital of Pittsburgh · USHôpital Necker-Enfants Malades · FRMedical University of Graz · ATMedizinische Hochschule Hannover · DEMontreal Children's Hospital · CARoyal Hospital for Children · GBSwiss Tropical and Public Health Institute · CH

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultChildCystic FibrosisExercise TherapyFeedback, PsychologicalFemaleFollow-Up StudiesHumansLungMaleMotivationPhysical Conditioning, HumanPhysical FitnessRespiratory Function TestsTreatment Outcomecystic fibrosisexercise capacityexercise programphysical activityrandomized controlled trial

Identifiers

PMID34735776
PMCPMC8887001
OpenAlexW3208534440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.