Evidence map›Paper›PMID 34735649›Full record

ReviewCurrent oncology reports2021

A New Generation of Vaccines in the Age of Immunotherapy.

Alfredo Addeo, Alex Friedlaender, Elisa Giovannetti, Alessandro Russo, Diego de Miguel-Perez, Oscar Arrieta, Andres F Cardona, Christian Rolfo

Open access · bronzeAbstract readReview
In one paragraph

Review in Current oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Vaccine approaches to treat urothelial cancer.Human vaccines & immunotherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 6 countries.

Alfredo AddeoOncology Department, Undivert Hospital, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-0988-0828
Alex FriedlaenderOncology Department, Undivert Hospital, Geneva, Switzerland.
Elisa GiovannettiDepartment of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-7565-7504
Alessandro RussoMedical Oncology Unit, A.O. Papardo, Messina, Italy.ORCID http://orcid.org/0000-0002-3365-1972
Diego de Miguel-PerezCenter for Thoracic Oncology The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, One Gustave Levy Place, Box 1079, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-2822-4466
Oscar ArrietaThoracic Oncology Unit, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.
Andres F CardonaFoundation for Clinical and Applied Cancer Research (FICMAC)/Clinical and Traslational Oncology Group, Clínica del Country/Molecular Oncology and Biology Systems Research Group (Fox-G), Universidad El Bosque, Bogotá, Colombia.ORCID http://orcid.org/0000-0003-3525-4126
Christian RolfoCenter for Thoracic Oncology The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, One Gustave Levy Place, Box 1079, New York, NY, 10029, USA. christian.rolfo@mssm.edu.ORCID http://orcid.org/0000-0002-5109-0267
Mount Sinai Health System · USUniversity Hospital of Geneva · CHAzienda Ospedaliera Ospedali Riuniti Papardo Piemonte · ITFondazione Pisa · ITInstituto Nacional de Cancerología · MXUniversidad El Bosque · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewCancer vaccines are one of the most extensively studied immunotherapy type in solid tumors. Despite favorable presuppositions, so far, the use of cancer vaccines has been associated with disappointing results. However, a new generation of vaccines has been developed, promising to revolutionize the immunotherapy field. RECENT

findingsIn this review, we aim to highlight the advances in cancer vaccines and the remaining hurdles to overcome. Cancer vaccination has experienced tremendous progress in the last decade, with myriad promising developments. Future efforts should focus on optimization of target identification, streamlining of most appropriate vaccination strategies, and adjuvant development, as well as predictive biomarker identification. Cautious optimism is warranted in the face of early successes seen in recent clinical trials for oncolytic vaccines. If an approach were to prove successful, it could revolutionize cancer therapy the way ICIs did in the previous decade.

Indexed as

Antigens, NeoplasmCancer VaccinesHumansImmunotherapyNeoplasmsAntigens, NeoplasmCancer VaccinesImmunotherapyLung cancerNSCLCVaccines

Identifiers

PMID34735649
PMCPMC8566658
OpenAlexW3209042196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.