Evidence map›Paper›PMID 34735613›Full record

ArticleAnnals of hematology2022

Eltrombopag in the treatment of patients with persistent thrombocytopenia after haploidentical peripheral blood stem cell transplantation: a single-center experience.

Fei Yan, Ning Lu, Zhenyang Gu, Wenrong Huang, Shuhong Wang, Xiaoning Gao, Liping Dou, Fei Li, Lili Wang, Meng Li and 2 more

Abstract read
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In one paragraph

Article in Annals of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Fei YanDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Ning LuDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Zhenyang GuDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Wenrong HuangDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Shuhong WangDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Xiaoning GaoDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Liping DouDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Fei LiDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Lili WangDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Meng LiDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Daihong LiuDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China.
Chunji GaoDepartment of Hematology, the Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100853, China. gaochunji301@163.com.
Chinese People's Liberation Army · CN

Funding

Beijing Natural Science Foundation 7202185
6 · The paper itself

Abstract

Persistent thrombocytopenia (PT) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with an increased risk of bleeding and poor survival. The exact pathogenesis underlying PT remains unclear, and its management is difficult. Here we conducted a retrospective study to evaluate the efficacy and safety of eltrombopag (EPAG) in 34 patients with PT after allo-HSCT. Seven patients suffered from prolonged isolated thrombocytopenia (PIT), and 27 had secondary failure of platelet recovery (SFPR). For most patients, the initial dose was 25 mg or 50 mg daily, then adjusted to the maximum dose of 50-100 mg per day according to the response of platelet recovery and toleration of patients. The cumulative incidence (CI) of platelet recovery to at least 20 × 10

Indexed as

Peripheral Blood Stem Cell TransplantationAdolescentAdultBenzoatesFemaleHumansHydrazinesMaleMiddle AgedPlatelet CountPyrazolesRetrospective StudiesThrombocytopeniaTransplantation ConditioningTreatment OutcomeYoung AdultBenzoateseltrombopagHydrazinesPyrazolesEfficacyEltrombopagPeripheral blood stem cell transplantationSafetyThrombocytopenia

Identifiers

PMID34735613
OpenAlexW3208946053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.