ArticlePsychopharmacology2022
Effects of average reward rate on vigor as a function of individual variation in striatal dopamine.
Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- The effects of haloperidol on motor vigour and movement fusion during sequential reaching.PloS one · 2025Trial
- Methylphenidate undermines or enhances divergent creativity depending on baseline dopamine synthesis capacity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learning and temporal discounting.PLoS computational biology · 2022Trial
- Article
- Striatal dopamine and skeletal muscle energy metabolism in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Sex-Dependent Attentional Impairments in a Subchronic Ketamine Mouse Model for Schizophrenia.Biological psychiatry global open science · 2024Article
- Exploring distinct and joint contributions of the locus coeruleus and the substantia nigra/ventral tegmental area complex to reward and valence processing using high-resolution fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
rationaleWe constantly need to decide not only which actions to perform, but also how vigorously to perform them. In agreement with an earlier theoretical model, it has been shown that a significant portion of the variance in our action vigor can be explained by the average rate of rewards received for that action. Moreover, this invigorating effect of average reward rate was shown to vary with within-subject changes in dopamine, both in human individuals and experimental rodents.
objectivesHere, we assessed whether individual differences in the effect of average reward rate on vigor are related to individual variation in a stable measure of striatal dopamine function in healthy, unmedicated participants.
methodsForty-four participants performed a discrimination task to test the effect of average reward rate on response times to index vigor and completed an [
resultsWe did not find an interaction between dopamine synthesis capacity and average reward rate across the entire group. However, a post hoc analysis revealed that participants with higher striatal dopamine synthesis capacity, particularly in the nucleus accumbens, exhibited a stronger invigorating effect of average reward rate among the 30 slowest participants.
conclusionsOur findings provide converging evidence for a role of striatal dopamine in average reward rate signaling, thereby extending the current literature on the mechanistic link between average reward rate, vigor, and dopamine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.