ArticlePLoS biology2021
An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Brain connectivity changes associated with acute sleep deprivation: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Article
- A neural signature of sleep deprivation in the human brain.Nature communications · 2026Article
- Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors.PLoS biology · 2025Article
- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Supercomplexity: bridging the gap between aesthetics and cognition.Frontiers in neuroscience · 2025Article
- Individualized rTMS Intervention Targeting Sleep Deprivation-Induced Vigilance Decline: Task fMRI-Guided Approach.CNS neuroscience & therapeutics · 2024Article
- Human brain state dynamics are highly reproducible and associated with neural and behavioral features.PLoS biology · 2024Article
- NREM sleep brain networks modulate cognitive recovery from sleep deprivation.bioRxiv : the preprint server for biology · 2024Article
- Human brain state dynamics reflect individual neuro-phenotypes.bioRxiv : the preprint server for biology · 2024Article
- A multidimensional investigation of sleep and biopsychosocial profiles with associated neural signatures.Research square · 2024Article
- Arousal impacts distributed hubs modulating the integration of brain functional connectivity.NeuroImage · 2022Article
- The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology.Frontiers in network physiology · 2022Article
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Sleep deprivation (SD) leads to impairments in cognitive function. Here, we tested the hypothesis that cognitive changes in the sleep-deprived brain can be explained by information processing within and between large-scale cortical networks. We acquired functional magnetic resonance imaging (fMRI) scans of 20 healthy volunteers during attention and executive tasks following a regular night of sleep, a night of SD, and a recovery nap containing nonrapid eye movement (NREM) sleep. Overall, SD was associated with increased cortex-wide functional integration, driven by a rise of integration within cortical networks. The ratio of within versus between network integration in the cortex increased further in the recovery nap, suggesting that prolonged wakefulness drives the cortex towards a state resembling sleep. This balance of integration and segregation in the sleep-deprived state was tightly associated with deficits in cognitive performance. This was a distinct and better marker of cognitive impairment than conventional indicators of homeostatic sleep pressure, as well as the pronounced thalamocortical connectivity changes that occurs towards falling asleep. Importantly, restoration of the balance between segregation and integration of cortical activity was also related to performance recovery after the nap, demonstrating a bidirectional effect. These results demonstrate that intra- and interindividual differences in cortical network integration and segregation during task performance may play a critical role in vulnerability to cognitive impairment in the sleep-deprived state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.