ArticleScience (New York, N.Y.)2021
Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
–field-weighted citation impact
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Who cites it
67 citing papers in PubMed.
- Multi-omics analysis identified SPRR2D as a potential biomarker for tumor prognosis and immune microenvironment infiltration: a pan-cancer perspective.Future science OA · 2026Article
- The SPRR2A-CSTA axis drives IL-17A-induced squamous metaplasia and steroid resistance in allergic rhinitis.The Journal of allergy and clinical immunology · 2026Article
- Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis.Medical review (2021) · 2026Review
- Tissue and cellular spatiotemporal dynamics in colon aging.Nature biotechnology · 2026Article
- NF-κB/AP-1-mediated expression of the porcine cathelicidin proPMAP-37 suppresses inflammation by neutralizing LPS and inhibiting M1 macrophage polarization.BMC veterinary research · 2026Article
- An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.Nature immunology · 2026Article
- Soybean-Derived Soluble Fiber Enhances Antimicrobial Proteins in the Mouse Small Intestine via a Tuft Cell-Group 2 Innate Lymphoid Cell Axis.Journal of agricultural and food chemistry · 2026Article
- Metatranscriptomic analysis of upper and lower respiratory tract microbiomes in patients with tuberculosis and community-acquired pneumonia.BMC infectious diseases · 2026Article
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity.Current opinion in immunology · 2026Review
- Intelectin-2 is a broad-spectrum antimicrobial lectin.Nature communications · 2026Article
- Salivary proteomics of patients with type 2 diabetes identify potential biomarkers for diabetes and highlight significant role of immune response.Clinical and experimental medicine · 2026Article
- Crosstalk between gut microbiota and RNA N6-methyladenosine modification in diabetic retinopathy.Frontiers in cell and developmental biology · 2026Review
- Multifunctional antimicrobial effects ofFrontiers in immunology · 2026Article
- Dietary pectin enhances intestinal antimicrobial protein expression via a tuft cell-ILC2-STAT6 signaling axis.Current research in food science · 2026Article
- Helminth reshapes host gut microbiota and immunoregulation by deploying an antimicrobial program of innate immunity.Gut microbes · 2025Article
- Commensal bacterial glycosylation at the interface of host-bacteria interactions.Gut microbes · 2025Review
- Article
- Linking the production of reactive oxygen species to the expression of antimicrobial peptides through aquaporin in an arthropod.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Zehan Hu *Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4648-5301
Chenlu Zhang *Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9462-9237
Luis Sifuentes-DominguezDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9525-071X
Christina M ZarekDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6211-5132
Daniel C PropheterDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8665-0885
Zheng KuangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5855-8371
Yuhao WangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4539-3720
Mihir PendseDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7810-6791
Kelly A RuhnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9440-8546
Brian HassellDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-0031-2173
Cassie L BehrendtDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0800-2353
Bo ZhangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8231-0875
Prithvi RajDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-4068-4358
Tamia A Harris-TryonDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4170-7083
Tiffany A ReeseDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2325-6546
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2759-4641
Funding
Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9MINTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4MDefining Mechanisms for Parasite-Driven Effects on Gamma-Herpesvirus LatencyR01AI130020 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Tiffany Anne Reese · 2018 to 2026
$3.7MThe Function of Small Proline Rich Proteins in Cutaneous Host DefenseK08AR076459 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI HARRIS-TRYON, TAMIA ALISHA · 2020 to 2024
$798kMicrobiota-dependent Epigenetic Regulation of Circadian Rhythms in Nutrient Uptake and Energy HomeostasisR00DK120897 · NIDDK · CARNEGIE-MELLON UNIVERSITY · PI KUANG, ZHENG · 2021 to 2023
$735kBehavioral quantification through active learning and multidimensional physiological monitoringR34DA059509 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI GROVER, PULKIT, KUANG, ZHENG · 2024 to 2025
$663kMicrobiota-dependent Epigenetic Regulation of Circadian Rhythms in Nutrient Uptake and Energy HomeostasisK99DK120897 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KUANG, ZHENG · 2019 to 2020
$182kHoward Hughes Medical InstituteNIAID NIH HHS R01 AI130020NIAID NIH HHS T32 AI005284NIAMS NIH HHS K08 AR076459NIDA NIH HHS R34 DA059509NIDDK NIH HHS K99 DK120897NIDDK NIH HHS R00 DK120897NIDDK NIH HHS R01 DK070855
Abstract
A diverse group of antimicrobial proteins (AMPs) helps protect the mammalian intestine from varied microbial challenges. We show that small proline-rich protein 2A (SPRR2A) is an intestinal antibacterial protein that is phylogenetically unrelated to previously discovered mammalian AMPs. In this study, SPRR2A was expressed in Paneth cells and goblet cells and selectively killed Gram-positive bacteria by disrupting their membranes. SPRR2A shaped intestinal microbiota composition, restricted bacterial association with the intestinal surface, and protected against
Indexed as
Gastrointestinal MicrobiomeNematospiroides dubiusAnimalsBacterial LoadCell MembraneCell Membrane PermeabilityCornified Envelope Proline-Rich ProteinsCytokinesDisease SusceptibilityGoblet CellsGram-Positive BacteriaHumansImmunity, InnateIntestinal MucosaIntestinesListeria monocytogenesCornified Envelope Proline-Rich ProteinsCytokinesPore Forming Cytotoxic ProteinsSprr2a1 protein, mouseSPRR2A protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.