ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021
Short-term step reduction reduces citrate synthase activity without altering skeletal muscle markers of oxidative metabolism or insulin-mediated signaling in young males.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Two-week step-reduction has limited negative effects on physical function and metabolic health in older adults.European journal of applied physiology · 2024Trial
- Musculoskeletal and physiological responses to vortex wave stimulation in older adults.The Journal of physiology · 2026Article
- Bed rest decreases resting skeletal muscle OExperimental physiology · 2026Article
- Reply: Muscle abnormalities in Long COVID.Nature communications · 2025Article
- Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies.Clinical science (London, England : 1979) · 2024Review
- Effects of Treadmill Running at Different Light Cycles in Mice with Metabolic Disorders.International journal of molecular sciences · 2023Article
- Prolonged sitting and peripheral vascular function: potential mechanisms and methodological considerations.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Mitochondria are critical to skeletal muscle contractile function and metabolic health. Short-term periods of step reduction (SR) are associated with alterations in muscle protein turnover and mass. However, the effects of SR on mitochondrial metabolism/muscle oxidative metabolism and insulin-mediated signaling are unclear. We tested the hypothesis that the total and/or phosphorylated protein content of key skeletal muscle markers of mitochondrial/oxidative metabolism, and insulin-mediated signaling would be altered over 7 days of SR in young healthy males. Eleven, healthy, recreationally active males (means ± SE, age: 22 ± 1 yr, BMI: 23.4 ± 0.7 kg·m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.