Evidence map›Paper›PMID 34734579›Full record

ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2021

Association between upper airway obstruction and malocclusion in mouth-breathing children.

Paola Festa, Nicola Mansi, Alfonso Maria Varricchio, Fabio Savoia, Camilla Calì, Carmela Marraudino, Giovanni Carlo De Vincentiis, Angela Galeotti

Open access · goldAbstract read
In one paragraph

Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Functional appliances and airway in class II malocclusion : An umbrella review and re-analysis of three meta-analyses.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
    Review
  4. Article
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  6. Article
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  9. Multidimensional analysis of the impact of adenoid hypertrophy on pediatric dentofacial and airway structures and construction of a diagnostic model.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  10. Observational
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  16. [Research progress on the influence of oral breathing on the growth and development of children's dental and maxillofacial region].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  17. Open Mouth Posture Syndrome (OMPS): Classification.Journal of clinical medicine · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Paola FestaOtorhinolaryngology Unit, AORN Santobono-Pausilipon, Naples, Italy.
Nicola MansiOtorhinolaryngology Unit, AORN Santobono-Pausilipon, Naples, Italy.
Alfonso Maria VarricchioOtorhinolaryngology Unit, AORN Santobono-Pausilipon, Naples, Italy.
Fabio SavoiaEvaluative Epidemiology-Childhood Cancer Registry of Campania, AORN Santobono-Pausilipon, Naples, Italy.
Camilla CalìEvaluative Epidemiology-Childhood Cancer Registry of Campania, AORN Santobono-Pausilipon, Naples, Italy.
Carmela MarraudinoDentistry Unit, AORN Santobono-Pausilipon, Naples, Italy.
Giovanni Carlo De VincentiisOtorhinolaryngology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Angela GaleottiDentistry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Bambino Gesù Children's Hospital · ITRegione Campania · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Buon Consiglio Fatebenefratelli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the association between upper airway obstruction and occlusal anomalies in mouth-breathing children.

methods356 mouth-breathing children were evaluated by ENT physicians and specialists in orthodontics. ENT examination included nasal endoscopy to assess the adenoidal hypertrophy, tonsillar grading and presence of nasal septum deviation. Clinical orthodontic examination was performed to record occlusal variables. Univariate and multivariable logistic regression were performed to study the association between registered variables.

results221 patients (mean age ± sd = 6.2 ± 2.5 years) met inclusion criteria. 81.4% of children presented malocclusion. A significant association between tonsillar grade 2 and the presence of malocclusion, Class II relation and increased overjet was shown. Tonsillar grade 4 showed a significant association with the presence of malocclusion and increased overjet. Adenoidal hypertrophy and nasal septum deviation did not show any association with occlusal findings.

conclusionsA high frequency of orthodontic problems was seen in mouth-breathing children. Our results suggested that severe tonsillar hypertrophy may determine presence of malocclusion and increased overjet. On the other hand, the association between mild tonsillar hypertrophy and many occlusal anomalies in mouth-breathers suggest an important role of malocclusion in the onset of oral breathing in children.

Indexed as

Airway ObstructionMalocclusionNasal ObstructionChildHumansMouthMouth BreathingNasal Septumadenoidsmalocclusionmouth-breathingnasal septum deviationtonsils

Identifiers

PMID34734579
PMCPMC8569668
OpenAlexW3210551572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.