Evidence map›Paper›PMID 34734483›Full record

ArticleCancer medicine2021

Age-specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi.

Megan A Clarke, Carolann Risley, Mary W Stewart, Kim R Geisinger, Laree M Hiser, Jody C Morgan, Kenyata J Owens, Krishna Ayyalasomayajula, Rhonda M Rives, Ashish Jannela and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  15. DNA from multiple viral species is associated with Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Megan A ClarkeClinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA.ORCID 0000-0003-0435-7376
Carolann RisleyClinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA.
Mary W StewartSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Kim R GeisingerWalter Reed National Military Medical Center, Armed Forces Joint Pathology Center, Bethesda, Maryland, USA.
Laree M HiserSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jody C MorganSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Kenyata J OwensSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Krishna AyyalasomayajulaSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Rhonda M RivesSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Ashish JannelaSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Dianne E GrunesDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Lei ZhangSchool of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Mark SchiffmanClinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA.
Sarah WagnerCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, USA.
Joseph BolandCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, USA.
Sara BassCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, USA.
Nicolas WentzensenClinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA.
University of Mississippi Medical Center · USCancer Genetics (United States) · USNational Cancer Institute · USJackson Memorial Hospital · USWalter Reed National Military Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundMississippi (MS) has among the highest rates of cervical cancer incidence and mortality in the United States, with disproportionately higher rates among Blacks compared to Whites. Here, we evaluate the prevalence of high-risk human papillomavirus (HPV) and abnormal cytology in a representative baseline sample from a diverse statewide cohort of individuals attending cervical screening in MS from the STRIDES Study (STudying Risk to Improve DisparitiES in cervical cancer).

methodsWe included individuals aged 21-65 years undergoing screening at the University of Mississippi Medical Center (UMMC) and the Mississippi State Department of Health (MSDH) from May to November 2018. We calculated age-specific HPV prevalence, overall and by partial HPV16/18 genotyping, and abnormal cytology by race.

resultsA total of 6871 individuals (mean age 35.7 years) were included. HPV prevalence was 25.6% and higher in Blacks (28.0%) compared to Whites (22.4%). HPV prevalence was significantly higher in Blacks aged 21-24 years (50.2%) and 30-34 years (30.2%) compared to Whites in the same age groups (32.1% and 20.7%; p < 0.0001, respectively). The prevalence of high-grade cytologic abnormalities, a cytologic sign of cervical precancer, peaked earlier in Blacks (ages 25-29) compared to Whites (35-39). For comparison, we also analyzed HPV prevalence data from the National Health and Nutrition Examination Survey (NHANES, 2013-2016) and observed similar racial differences in HPV prevalence among women aged 21-24 years.

conclusionsOur findings suggest that Blacks undergoing cervical cancer screening in MS have higher prevalence of other high-risk 12 HPV types at younger ages and experience an earlier peak of high-grade cytologic abnormalities compared to Whites.

Indexed as

AdultAgedAge FactorsFemaleGenotypeHumansMiddle AgedMississippiPapillomavirus InfectionsPrevalenceProspective StudiesUterine Cervical Neoplasmscervical cancerhuman papillomavirusMississippinatural historyracial differences

Identifiers

PMID34734483
PMCPMC8633239
OpenAlexW3207999381

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.