Evidence map›Paper›PMID 34734426›Full record

ReviewThe Prostate2022

Prostate cancer research in the 21st century; report from the 2021 Coffey-Holden prostate cancer academy meeting.

Andrea K Miyahira, Jelani C Zarif, Catherine C Coombs, Robert R Flavell, Joshua W Russo, Samir Zaidi, Di Zhao, Shuang G Zhao, Kenneth J Pienta, Howard R Soule

Abstract readReview
In one paragraph

Review in The Prostate, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea K MiyahiraDepartment of Science, Prostate Cancer Foundation, Santa Monica, California, USA.ORCID 0000-0003-4976-002X
Jelani C ZarifDepartment of Oncology, Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.ORCID 0000-0003-3880-2124
Catherine C CoombsDivision of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-8694-1199
Joshua W RussoDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0001-5481-0090
Samir ZaidiHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Di ZhaoDepartment of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-6253-7127
Shuang G ZhaoDepartment of Human Oncology, Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin, USA.
Kenneth J PientaThe James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Howard R SouleDepartment of Science, Prostate Cancer Foundation, Santa Monica, California, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Targeting Tumor Microenvironment-Induced Therapy Resistance in Prostate Cancer Bone MetastasisP50CA140388 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI THOMPSON, TIMOTHY CHARLES · 2009 to 2022
$23.4M
A novel immunoPET imaging agent to guide treatment planning in lethal prostate cancerR37CA251980 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLAVELL, ROBERT RICHARD · 2021 to 2021
$662k
Targeting M2-Tumor Associated Macrophages to overcome tumor immunity in metastatic castration-resistant prostate cancerK22CA237623 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZARIF, JELANI CHINELO · 2019 to 2021
$461k
Novel Therapeutic Approaches Targeting Tumor Suppressor Deficiencies in Advanced Prostate CancerK99CA226360 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ZHAO, DI · 2018 to 2018
$92k
NCI NIH HHS K22 CA237623NCI NIH HHS K99 CA226360NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014520NCI NIH HHS P30 CA082103NCI NIH HHS P50 CA140388NCI NIH HHS R37 CA251980
6 · The paper itself

Abstract

introductionThe 2021 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Prostate Cancer Research in the 21st Century," was held virtually, from June 24-25, 2021.

methodsThe CHPCA Meeting is organized by the Prostate Cancer Foundation as a unique discussion-oriented meeting focusing on critical topics in prostate cancer research envisioned to bridge the next major advances in prostate cancer biology and treatment. The 2021 CHPCA Meeting was virtually attended by 89 investigators and included 31 talks over nine sessions.

resultsMajor topic areas discussed at the meeting included: cancer genomics and sequencing, functional genomic approaches to studying mediators of plasticity, emerging signaling pathways in metastatic castration resistant prostate cancer, Wnt signaling biology and the challenges of targeted therapy, clonal hematopoiesis, neuroendocrine cell plasticity and antitumor immunity, cancer immunotherapy and its synergizers, and imaging the tumor microenvironment and metabolism. DISCUSSION: This meeting report summarizes the research presented at the 2021 CHPCA Meeting. We hope that publication of this knowledge will accelerate new understandings and the development of new biomarkers and treatments for prostate cancer.

Indexed as

ProstateProstatic NeoplasmsCongresses as TopicHumansImmunotherapyMaleResearchcancer immunotherapymolecular imagingprecision medicinetherapeuticstumor genomics

Identifiers

PMID34734426
PMCPMC8688282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.