SynthesisClinical cardiology2021
Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction: A meta-analysis.
Synthesis in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction: A meta-analysis.Clinical cardiology · 2021Pooled it
- Valve morphology and timing of surgery in bicuspid aortic valve disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Aortic Regurgitation: An Updated Review of Etiologies, Diagnostic Strategies, and Clinical Management.Reviews in cardiovascular medicine · 2025Review
- The Role of Paraoxonase-1 Activity, Apolipoprotein B Levels, and Apolipoprotein B/Apolipoprotein A-I Ratio as Risk Markers for Aortic Stenosis in Patients with a Bicuspid Aortic Valve.Antioxidants (Basel, Switzerland) · 2025Article
- Bicuspid Aortic Valve, from the Unknown till the Perfection of the Species.Reviews in cardiovascular medicine · 2024Review
- Patients with a Bicuspid Aortic Valve (BAV) Diagnosed with ECG-Gated Cardiac Multislice Computed Tomography-Analysis of the Reasons for Referral, Classification of Morphological Phenotypes, Co-Occurring Cardiovascular Abnormalities, and Coronary Artery Stenosis.Journal of clinical medicine · 2024Article
- [Interventional treatment in an adult: postductal aortic coarctation, aortic stenosis and persistence of the ductus arteriosum].Archivos de cardiologia de Mexico · 2024Article
- Computed Tomography and Magnetic Resonance Imaging Findings of Bicuspid Aortic Valve and Related Abnormalities of the Heart and Thoracic Aorta.Korean journal of radiology · 2023Review
- Aortic Valve Dysfunction and Aortopathy Based on the Presence of Raphe in Patients with Bicuspid Aortic Valve Disease.Journal of cardiovascular development and disease · 2023Article
- Association of Myocardial Changes and Gene Expression of theChildren (Basel, Switzerland) · 2023Article
- The Natural History of Bicuspid Aortic Valve Disease.Structural heart : the journal of the Heart Team · 2023Review
- Echocardiography in Simple Congenital Heart Diseases: Guiding Adult Patient Management.Journal of cardiovascular echographyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundValvular dysfunction is a common complication in patients with bicuspid aortic valves (BAV). The aim of this study was to determine the relationship between BAV morphology patterns and valve dysfunction.
methodsWe searched the PubMed, The Cochrane Library, Web of Science, and CNKI until May 31, 2020, to identify all studies investigating the morphology of BAV and valvular dysfunction, and data were extracted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Data were analyzed using Stata 15.1 software. The additional characteristics (gender, mean age) were collected to perform a meta-regression analysis.
resultsThirteen studies on BAV-RL (n = 2002) versus BAV-RN (n = 1254) and raphe (n = 4001) versus without raphe (n = 673) were included. The BAV-RL patients showed a higher incidence of aortic regurgitation than BAV-RN patients (OR = 1.46; 95% CI: 1.12 to 1.90, p = .005), while the BAV-RL patients showed a lower incidence of aortic stenosis than BAV-RN patients (OR = 0.66, 95% CI: 0.58 to 0.76, p = .000); BAV patients with raphe presents a higher incidence of aortic regurgitation than those without raphe (OR = 1.95, 95% CI: 1.12-3.39, p = .017). No differences were found between raphe and without raphe group in the incidence of aortic stenosis (OR = 0.97, 95% CI: 0.53 to 1.76, p = .907). Mean age and gender had no influence on observed differences.
conclusionsOur results confirmed a relationship between different BAV phenotypes and aortic valve dysfunction. BAV-RL and BAV with raphe are more likely to develop aortic regurgitation, while patients with BAV-RN present a higher possibility to develop aortic stenosis.
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