Evidence map›Paper›PMID 34734414›Full record

ArticleMedical physics2021

Bladder surface dose modeling in prostate cancer radiotherapy: An analysis of motion-induced variations and the cumulative dose across the treatment.

Yi Lao, Minsong Cao, Yingli Yang, Amar U Kishan, Wensha Yang, Yalin Wang, Ke Sheng

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In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yi LaoDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.
Minsong CaoDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.
Yingli YangDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.
Amar U KishanDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.
Wensha YangDepartment of Radiation Oncology, University of Southern California, Los Angeles, California, USA.
Yalin WangSchool of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, Arizona, USA.
Ke ShengDepartment of Radiation Oncology, University of California, Los Angeles, California, USA.

Funding

Robust IMPT with automated beam orientation and scanning spot optimizationR01CA230278 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHENG, KE · 2019 to 2023
$1.9M
Motion Management of Pancreatic Cancer in MRI-Guided RadiotherapyR01CA188300 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHENG, KE · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA188300NCI NIH HHS R01 CA230278
6 · The paper itself

Abstract

purposeTo introduce a novel surface-based dose mapping method to improve quantitative bladder dosimetric assessment in prostate cancer (PC) radiotherapy.

methodsBased on the planning and daily pre and postfraction MRIs of 12 PC patients, bladder surface models (SMs) were generated on manually delineated contours and regionally aligned via surface-based registration. Subsequently, bladder surface dose models (SDMs) were created using face-wise dose sampling. To determine the bladder intrafractional and interfractional motion and dose variation, we performed a pose analysis between pre and postfraction bladder SMs, as well as surface mapping for fractional SMs. Discrepancies between the received dose, accumulated from daily SDMs, and the planned dose were then assessed on the corresponding SDMs. Complementary to the surface dose mapping, dose surface histogram (DSH)-based comparisons were also performed.

resultsThe intrafraction pose analysis revealed a significant (p < 0.05) bladder expansion, as well as an anterior/superior drift during the treatment. The intrafraction motion substantially altered dose to mid-bladder body, but not the bladder surface areas distal to or contiguous with the target. A similar pattern of dose variations was also detected by interfraction comparisons. With surface registration to the common SM, the cumulative bladder dose significantly differs from the planned dose. The discrepancy is evident in the mid-posterior range that corresponds to a mid- to high-dose region. The received DSH significantly differs from the planned DSH after permutation correction (p = 0.0122), while the overall surface-based comparison after multiple comparison correction is nonsignificant (p = 0.0800).

conclusionsWe developed a novel surface-based intra and interdose mapping framework applied to a unique daily MR dataset for image-guided radiotherapy. The framework identified significant intrafraction bladder positional changes, localized the intra and interfraction variations, and quantified planned versus received dose differences on the bladder surface. The result indicates the importance of adopting the motion-integrated bladder SDM for bladder dose management.

Indexed as

Prostatic NeoplasmsRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedHumansMaleRadiotherapy DosageRadiotherapy Planning, Computer-AssistedUrinary Bladderbladder motionsprostate cancersurface-based registrationsurface dose model

Identifiers

PMID34734414
PMCPMC8683601

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