Evidence map›Paper›PMID 34734252›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Appendicular Lean Mass, Grip Strength, and the Development of Hospital-Associated Activities of Daily Living Disability Among Older Adults in the Health ABC Study.

James S Andrews, Laura S Gold, May J Reed, Jose M Garcia, Robyn L McClelland, Annette L Fitzpatrick, Catherine L Hough, Peggy M Cawthon, Ken E Covinsky

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In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Appendicular Lean Mass, Grip Strength, and the Incidence of Dementia Among Older Adults in the Health ABC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  7. Article
  8. Review
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James S AndrewsDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2302-4358
Laura S GoldDepartment of Radiology, University of Washington, Seattle, Washington, USA.
May J ReedDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jose M GarciaDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Robyn L McClellandDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Annette L FitzpatrickDepartments Family Medicine, Epidemiology, and Global Health, University of Washington, Seattle, Washington, USA.
Catherine L HoughDepartment of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, University of California San Francisco, San Francisco, California, USA.
Ken E CovinskyDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENNETH E. COVINSKY · 2013 to 2026
$19.9M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Sarcopenia as a Predictor of Hospital-Associated Disability in Older AdultsK23AG058756 · NIA · UNIVERSITY OF WASHINGTON · PI ANDREWS, JAMES · 2018 to 2022
$1.6M
Sarcopenia as a Predictor of Functional Outcomes of Acute Illness in Older Adults with DementiaR03AG063168 · NIA · UNIVERSITY OF WASHINGTON · PI ANDREWS, JAMES · 2019 to 2020
$311k
BLRD VA I01 BX002807NIA NIH HHS K23 AG058756NIA NIH HHS P30 AG044281NIA NIH HHS R01 AG028050NIA NIH HHS R03 AG063168NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

backgroundHalf of all physical disability, including activity of daily living (ADL) disability, among older adults occurs in the setting of hospitalization. This study examines whether appendicular lean mass (ALM) and grip strength, which are commonly included in various definitions of sarcopenia, are associated with the development of hospital-associated ADL disability in older adults in the Health ABC Study.

methodsIndividuals hospitalized during the first 5 years of follow-up (n = 1 724) were analyzed. ALM to body mass index (BMI) ratio (ALMBMI), by dual-energy x-ray absorptiometry (DXA), and grip strength, by hand-held dynamometery, were assessed annually. Development of new ADL disability was assessed at the time of the next annual assessment after hospitalization. Separate regression analyses modeled the association of prehospitalization ALMBMI or grip strength with death before the next scheduled annual assessment. Next, among those who survived to the next annual assessment, separate regression analyses modeled the association of ALMBMI or grip strength with development of ADL disability.

resultsEach standard deviation decrement in prehospitalization grip strength was associated with an adjusted 1.80 odds of new ADL disability at follow-up (95% CI: 1.18, 2.74). Low, compared with not low, grip strength (per FNIH definition) was associated with an adjusted 2.36 odds of ADL disability at follow-up (95% CI: 1.12, 4.97). ALM measures were not associated with the development of hospital-associated ADL disability. ALM and grip strength measures were not associated with death.

conclusionsPrehospitalization lower grip strength may be an important risk factor for ADL disability among older adult survivors of hospitalization.

Indexed as

Activities of Daily LivingSarcopeniaAbsorptiometry, PhotonAgedBody CompositionHand StrengthHospitalsHumansActivities of daily livingGrip strengthHospital-associated disabilityLean massSarcopenia

Identifiers

PMID34734252
PMCPMC9255680

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.