ArticleThe American journal of clinical nutrition2022
Male waist circumference in relation to semen quality and partner infertility treatment outcomes among couples undergoing infertility treatment with assisted reproductive technologies.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Puerarin ameliorates obesity-induced spermatogenic dysfunction by targeting GRP78/StAR to increase testosterone synthesis.Journal of translational medicine · 2026Article
- The influence of body mass index on oxidative stress markers in infertile men's semen parameters.Clinical and experimental reproductive medicine · 2026Article
- Mediterranean Diet Adherence, Fatty Acid Profiles, and Early Assisted Reproduction Outcomes: Findings from a 12-Week Dietary Intervention.Medicina (Kaunas, Lithuania) · 2026Article
- Combined assessment of body mass index and triglyceride-glucose index reveals metabolic risk phenotypes associated with semen quality impairment.Frontiers in endocrinology · 2026Article
- Efficacy of Lingji Formula in the Treatment of Male Infertility in Obese Men: Study Protocol for a Randomized Controlled Trial.International journal of general medicine · 2026Article
- Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health.Molecular nutrition & food research · 2025Review
- Is a Large Neck Circumference a Predictive Factor for Poor Semen Quality in the Turkish Population?Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Association between body roundness index and female infertility: a cross-sectional study of NHANES 2013-2018.Frontiers in nutrition · 2024Article
- A North American study of anthropometric factors and semen quality.Fertility and sterility · 2023Article
- Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013-2020.BMC public health · 2023Article
- Occupational factors and markers of testicular function among men attending a fertility center.Human reproduction (Oxford, England) · 2023Observational
- Identification of Homozygous Regions With Adverse Effects on the Five Economic Traits of Duroc Pigs.Frontiers in veterinary science · 2022Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMale obesity has been related to poor semen quality and may also have a negative effect on assisted reproductive technologies (ART) outcomes. Whether male waist circumference (WC), as a measure of central obesity, impacts a couple's fertility independently of BMI is unclear.
objectivesTo examine the associations of male WC with semen quality and couples' outcomes of infertility treatment with ART.
methodsCouples presenting to the Massachusetts General Hospital Fertility Center were invited to participate in the study. Between 2009 and 2019, 269 males provided 671 semen samples and 176 couples underwent 317 ART cycles. Height, weight, and WC were measured on site. We analyzed the association of male WC with semen quality and pregnancy outcomes using cluster-weighted regression models to account for repeated observations while adjusting for potential confounders. Models were also stratified by male BMI (<25 kg/m2 compared with ≥25 kg/m2).
resultsThe median male age, WC, and BMI were 36.1 years, 96.0 cm, and 26.8 kg/m2, respectively. A 5-cm increase in WC was associated with a 6.3% (95% CI, 2.1-10.5%) lower sperm concentration after adjustment for potential confounders, including BMI. Male WC was also inversely related to the probability of achieving a live birth. For each 5-cm increase in male WC, the odds of a live birth per initiated cycle decreased by 9.0% (95% CI, 1.1%-16.4%) after accounting for several anthropometric and demographic characteristics of both partners. These associations were stronger among males in the normal BMI category (<25 kg/m2) than among overweight or obese males.
conclusionsA higher male WC may be an additional risk factor for poor outcomes of infertility treatment, even after accounting for male and female partner BMIs, particularly in couples where the male partner has a normal BMI.
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