Evidence map›Paper›PMID 34734208›Full record

ArticleCell reports methods2021

Systematic detection of m

Kyung Lock Kim, Peter van Galen, Volker Hovestadt, Gilbert J Rahme, Ekaterina N Andreishcheva, Abhijeet Shinde, Elizabeth Gaskell, Daniel R Jones, Efrat Shema, Bradley E Bernstein

Abstract read
In one paragraph

Article in Cell reports methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. RNA mCell biology and toxicology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyung Lock KimDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Peter van GalenDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Volker HovestadtDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Gilbert J RahmeDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ekaterina N AndreishchevaSeqLL Inc., Woburn, MA 01801, USA.
Abhijeet ShindeSeqLL Inc., Woburn, MA 01801, USA.
Elizabeth GaskellDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Daniel R JonesSeqLL Inc., Woburn, MA 01801, USA.
Efrat ShemaDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Bradley E BernsteinDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Funding

Single-molecule systems for decoding combinatorial chromatin modificationsR01HG009269 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI BERNSTEIN, BRADLEY EVAN · 2016 to 2019
$2.7M
Epigenetic Induction of Gliomagenesis in Neural Progenitor CellsF32CA236432 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, GILBERT J · 2019 to 2021
$195k
NCI NIH HHS F32 CA236432NHGRI NIH HHS R01 HG009269
6 · The paper itself

Abstract

Epigenetic modifications control the stability and translation of mRNA molecules. Here, we present a microscopy-based platform for quantifying modified RNA molecules and for relating the modification patterns to single-cell phenotypes. We directly capture mRNAs from cell lysates on oligo-dT-coated coverslips, then visually detect and sequence individual m

Indexed as

In Situ Hybridization, FluorescenceAntigens, CD34RNA, MessengerAntigens, CD34RNA, Messenger

Identifiers

PMID34734208
PMCPMC8562683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.