Evidence map›Paper›PMID 34734193›Full record

ArticleHGG advances2021

Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.

Daokun Sun, Melissa Richard, Solomon K Musani, Yun Ju Sung, Thomas W Winkler, Karen Schwander, Jin Fang Chai, Xiuqing Guo, Tuomas O Kilpeläinen, Dina Vojinovic and 125 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Susceptibility to hypertension based onFrontiers in cardiovascular medicine · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

135 authors.

Daokun SunBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Melissa RichardBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, 93040, Germany.
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jin Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, 119228, Singapore.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Hugues AschardDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Traci M BartzCardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98195, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Kumaraswamy ChitralaHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Fernando P HartwigPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS 96010-610, Brazil.
Andrea R V R HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP 01246-903, Brazil.
Yongmei LiuDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC 27701, USA.
Alisa K ManningClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Raymond NoordamSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2311 EZ, The Netherlands.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48108, USA.
Sarah E HarrisDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33101, Finland.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Rujia WangDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17489, Germany.
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Lisa R YanekDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Donna K ArnettDean's Office, University of Kentucky College of Public Health, Lexington, KY 40563, USA.
Ana BaracMedStar Heart and Vascular Institute, Washington, DC 20010, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Aravinda ChakravartiCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Martha L DavigulusDivision of Minority Health, Department of Epidemiology, University of Illinois, Chicago, IL, USA.
Lisa de las FuentesCardiovascular Division, Department of Medicine, Washington University, St. Louis, MO, USA.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2311 EZ, The Netherlands.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Joseph A C DelaneyCollege of Pharmacy, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Ana V Diez RouxDepartment of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA 19104, USA.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, 17489, Germany.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA.
Amanda M FrettsCardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98195, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Hans Jörgen GrabeDepartment Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, 17489, Germany.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Catharina C A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Sami HeikkinenInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70100, Finland.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Carmen IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY 10461, USA.
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Jost Bruno JonasDepartment of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY 10461, USA.
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Jose E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP 01246-903, Brazil.
Daniel LevyNHLBI Framingham Heart Study, Framingham, MA 01702, USA.
Lifelines Cohort Study
Jianjun LiuGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138632, Singapore.
Kurt LohmanDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC 27701, USA.
Annemarie I LuikDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Lisa W MartinDivision of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The Netherlands.
Jeff R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Walter R PalmasDivision of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Laura Pulkki-RåbackFaculty of Medicine, Department of Psychology and Logopedics, University of Helsinki, Helsinki, 0100, Finland.
Leslie J RaffelDivision of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA 92697, USA.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Jennifer G RobinsonDepartments of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2311 EZ, The Netherlands.
Carsten Oliver SchmidtInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17489, Germany.
Pamela J SchreinerDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Lars SchwettmannInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Stephen SidneyDivision of Research, Kaiser Permanente of Northern California, Oakland, CA 94612, USA.
Mario SimsJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA 98195, USA.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
E Shyong TaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.
Kent TaylorThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Hwee-Lin WeeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, 119228, Singapore.
Wen-Bin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Gregory WilsonJackson Heart Study, School of Public Health, Jackson State University, Jackson, MS 39217, USA.
Deng XuanDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Donglin ZengDepartment of Biostatistics, University of North Carolina Gilling School of Global Public Health, Chapel Hill, NC 27599, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Xiaofeng ZhuDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Alan B ZondermanBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21201, USA.
Diane M BeckerDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ian J DearyDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Timo A LakkaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33101, Finland.
Kari E NorthDepartment of Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, NC 27599, USA.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Ya-Xing WangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Michele K EvansHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
W James GaudermanBiostatistics, Preventive Medicine, University of Southern California, Los Angeles, CA 90007, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, 201, Iceland.
Bernardo L HortaPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS 96010-610, Brazil.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2311 EZ, The Netherlands.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP 01246-903, Brazil.
Bruce M PsatyCardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98195, USA.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Ervin R FoxCardiology, Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, 119228, Singapore.
Laura BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, NC 27599, USA.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Funding

Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3M
NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from 5 ancestry groups. In the combined meta-analyses of Stages 1 and 2, we identified 59 loci (p value <5e-8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (

Identifiers

PMID34734193
PMCPMC8562625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.