Evidence map›Paper›PMID 34734009›Full record

ArticleAnnals of translational medicine2021

Expression of tiRNA and tRF in

Honglin Lu, Lin Liu, Shu Han, Binbin Wang, Jin Qin, Kailin Bu, Yingzhen Zhang, Zhongzhong Li, Lina Ma, Jing Tian and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. [Abnormal transfer RNA epigenetic modifications and related impact on neurodegenerative diseases].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Honglin LuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lin LiuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Shu HanDepartment of Electrocardiogram, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Binbin WangDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jin QinDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Kailin BuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Yingzhen ZhangDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Zhongzhong LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lina MaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jing TianDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Kun ZhangDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Tong LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Huixian CuiDepartment of Anatomy, Hebei Medical University, Shijiazhuang, China.
Xiaoyun LiuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Second Hospital of Hebei Medical University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscriptomics, such as that of non-coding RNA (ncRNA), which include microRNA (miRNA), circular RNA, and the transfer RNA (tRNA)-derived fragments (tiRNA and tRF) in Alzheimer's disease (AD) have attracted much attention recently. The tiRNA and tRFs are produced when the tRNA splits at specific sites. The expression change and related function of tiRNA and tRFs in AD has not been fully investigated.

methodsIn our study,

resultsA total of 27 significantly different tiRNA and tRFs were detected between wild type (WT) and

conclusionsThe

Indexed as

Alzheimer’s disease (AD)APP/PS1 transgenic micecalcium dysregulationretinol metabolismtiRNA and tRFs

Identifiers

PMID34734009
PMCPMC8506760
OpenAlexW3202271691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.