Evidence map›Paper›PMID 34734004›Full record

ArticleAnnals of translational medicine2021

The important roles and molecular mechanisms of annexin A

Qing Ye, Yingying Zhang, Jieqiu Zhuang, Ye Bi, Hong Xu, Qian Shen, Jialu Liu, Haidong Fu, Jingjing Wang, Chunyue Feng and 15 more

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Serum Factors in Primary Podocytopathies.Antibodies (Basel, Switzerland) · 2025
    Review
  5. Targeting B Cells and Plasma Cells in Glomerular Disease.Journal of the American Society of Nephrology : JASN · 2025
    Review
  6. Article
  7. Review
  8. Autoantibodies Targeting Proteasome Subunit Alpha Type 1 in Autoimmune Podocytopathies.Journal of the American Society of Nephrology : JASN · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Minimal Change Disease: Pathogenetic Insights from Glomerular Proteomics.International journal of molecular sciences · 2024
    Article
  14. Steroid-Resistant Nephrotic Syndrome due toKidney international reports · 2024
    Article
  15. Article
  16. Cytoskeleton Rearrangement in Podocytopathies: An Update.International journal of molecular sciences · 2024
    Review
  17. Editorial: Insights in glomerular disease.Frontiers in nephrology · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 1 country.

Qing YeDepartment of Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Yingying ZhangDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Jieqiu ZhuangDepartment of Pediatric Nephrology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Ye BiDepartment of Pediatric Nephrology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Hong XuDepartment of Nephrology, Children's Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China.
Qian ShenDepartment of Nephrology, Children's Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China.
Jialu LiuDepartment of Nephrology, Children's Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China.
Haidong FuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Jingjing WangDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Chunyue FengDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xiaoxiao TangDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Fei LiuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Weizhong GuDepartment of Pathology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Fei ZhaoDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Jianjiang ZhangDepartment of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuanhan QinDepartment of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shiqiang ShangDepartment of Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Hongqiang ShenDepartment of Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xuejun ChenDepartment of Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Huijun ShenDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Aimin LiuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Yonghui XiaDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Zhihong LuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Qiang ShuDepartment of Thoracic and Cardiovascular Surgery, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Jianhua MaoDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Children's Hospital of Zhejiang University · CNChildren's Hospital of Fudan University · CNWenzhou Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNGuangxi Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, B-cell dysfunction has been found to play an important role in the pathogenesis of primary nephrotic syndrome (PNS). B cells play a pathogenic role by secreting antibodies against their target antigens after transforming into plasma cells. Therefore, this study aimed to screen the autoantibodies that cause PNS and explore their pathogenic mechanisms.

methodsWestern blotting and mass spectrometry were employed to screen and identify autoantibodies against podocytes in children with PNS. Both

resultsAnnexin A

conclusionsAnnexin A

Indexed as

Chronic kidney diseasecytoskeletonnephrotic syndromepediatric nephrologypodocyte

Identifiers

PMID34734004
PMCPMC8506724
OpenAlexW3197527798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.