Evidence map›Paper›PMID 34734003›Full record

ArticleAnnals of translational medicine2021

Profiles of messenger RNAs and MicroRNAs in hypoxia-induced hepatic stellate cells.

Liting Zhang, Jing Gao, Dan Zhou, Xiaojun Wang, Junfeng Li, Juan Wang, Hong Chen, Xiaodong Xie, Tuo Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Liting ZhangState Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China.
Jing GaoRespiratory Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Dan ZhouDepartment of Liver Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Xiaojun WangDepartment of Respiratory Medicine, Gansu Provincial Hospital, Lanzhou, China.
Junfeng LiDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Juan WangDepartment of Gastroenterology, Xi'an International Medical Center, Xi'an, China.
Hong ChenDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Xiaodong XieInstitute of Medical Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Tuo ChenState Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China.
First Hospital of Lanzhou University · CNLanzhou University · CNXi’an International University · CNChinese Academy of Sciences · CNGansu Provincial Hospital · CNKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroRNA (miRNA) plays an important role in hepatic stellate cell (HSCs) activation and liver fibrosis. The purpose of this study is to explore the effect of hypoxia on the differential expression of mRNAs and miRNAs in rat HSCs.

methodsHSC-T6 cells were treated with cobalt chloride (CoCl

resultsWith the increase of CoCl

conclusionsOur results presented the profiles of mRNAs and miRNAs in hypoxia-induced HSC-T6 cells in rats, the signaling pathways, and co-expression networks. These findings may suggest novel insights for the early diagnosis and treatment of HSC activation and liver fibrosis.

Indexed as

genome sequencingHypoxiahypoxia inducible factor-1 alpha (HIF-1α)miRNArat hepatic stellate cells (HSCs)

Identifiers

PMID34734003
PMCPMC8506783
OpenAlexW3202502112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.