Evidence map›Paper›PMID 34733780›Full record

ArticleFrontiers in oncology2021

Case Report: Targeted Therapy for Metastatic Solid Pseudopapillary Neoplasm of the Pancreas With

Xinbo Wang, Daojun Zhu, Wei Bao, Min Li, Sizhen Wang, Rongxi Shen

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xinbo WangResearch Institute of General Surgery, Jinling Hospital, Nanjing University Medical School, Nanjing, China.
Daojun ZhuResearch Institute of General Surgery, Jinling Hospital, Nanjing University Medical School, Nanjing, China.
Wei BaoDepartment of Clinical Pathology, Jinling Hospital, Nanjing University Medical School, Nanjing, China.
Min LiResearch Institute of General Surgery, Jinling Hospital, Nanjing University Medical School, Nanjing, China.
Sizhen WangResearch Institute of General Surgery, Jinling Hospital, Nanjing University Medical School, Nanjing, China.
Rongxi ShenResearch Institute of General Surgery, Jinling Hospital, Nanjing University Medical School, Nanjing, China.
Jinling Institute of Technology · CNNanjing University · CNNanjing General Hospital of Nanjing Military Command · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSolid pseudopapillary neoplasm (SPN) of the pancreas shows an indolent clinical behavior in cases undergoing surgical resection. The efficacy of combination therapy in the metastatic extrapancreatic SPN treatment remains largely unknown and a clinical challenge. CASE PRESENTATION: We report a case of a metastatic pancreatic SPN in a 45-year-old woman who presented with an aggressive peritoneal dissemination and hepatic metastases and still showed an indolent clinical course with combination therapy with repeated surgery and targeted therapy. Although the follow-up effect remains to be seen, this is the first report of practical experience of the targeted agents sunitinib and everolimus in metastatic SPN tumors based on the mutation status of

conclusionEvidence on variant genetics indicates that future molecular studies may not only help to explain the mechanism of SPN occurrence and development but are also more likely to direct to future precision treatments.

Indexed as

everolimusmetastasispancreassolid pseudopapillary neoplasm (SPN)sunitinibtargeted therapy

Identifiers

PMID34733780
PMCPMC8558400
OpenAlexW3205140519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.