ArticleTranslational pediatrics2021
Polymorphisms in the interleukin 4 promoter -589C/T gene and the risk of asthma: a systematic review and meta-analysis.
Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- From Susceptibility to Severity: The Impact of Interleukin-33 rs1929992 Polymorphism on Asthma in a Taiwanese Population.Life (Basel, Switzerland) · 2026Article
- From Susceptibility to Disease Severity: Re-Discovering the Clinical Role ofLife (Basel, Switzerland) · 2026Article
- IL5 rs2069812 and IL13 rs1800925 Genetic variants as key determinants of clinically relevant asthma phenotypes.PloS one · 2026Article
- Impact of Interleukin-17 Receptor A Gene Variants on Asthma Susceptibility and Clinical Manifestations in Children and Adolescents.Children (Basel, Switzerland) · 2024Article
- The association between polymorphisms in the interleukin 4 (IL-4) promoter -589C/T gene and the risk of asthma.Translational pediatrics · 2022Article
- Polymorphisms in HumanGenes · 2022Article
- Associations of Matrix Metalloproteinase-7 Promoter Genotypes With Asthma Risk in Taiwan.In vivo (Athens, Greece)Article
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo identify the association between polymorphisms in the interleukin 4 (IL-4) promoter -589C/T gene and the risk of asthma.
methodsThe databases of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Chongqing VIP (CQVIP), and Chinese Biomedical Literature (CBM) were searched and appropriate journal articles on the association between polymorphisms in the IL-4 promoter -589C/T gene and the risk of asthma were retrieved from establishment of the database to April 2021. All relevant randomized controlled trials (RCTs) were included, to the exclusion of duplicate publications, studies with no whole composition, imperfect information or inability to extract data, animal experiments and reviews, and systematic reviews. The software Review manager 5.3 was used to analyze the data.
resultsLiterature search led to retrieving of 16 publications containing 3181 cases and 3786 controls. The results show that CT, CC, and T gene polymorphisms were risk factors for asthma [odds ratio (OR) =1.05, 95% confidence interval (CI): 0.89-1.24; OR =1.04, 95% CI: 0.85-1.27; OR =1.98, 95% CI: 1.54-2.53]. Ethnic subgroup analysis showed that genotype CT was associated with the risk of asthma in the Asian population (OR =1.75, 95% CI: 1.01-3.05). DISCUSSION: Through the study of IL-4 (C-590T) gene polymorphism, it was found that CT, TT, and T gene polymorphism were risk factors for asthma, and the results suggested that this locus polymorphism was related to the risk of asthma. The results of subgroup analysis showed that CC and T gene polymorphisms were risk factors for asthma. Thus, IL-4(C-590T) may be the susceptibility gene of asthma.
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