ReviewWorld journal of psychiatry2021
Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression.
Review in World journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review.Frontiers in medicine · 2023Pooled it
- Beyond bendy joints: number of variant connective tissue features predicts neurodivergent characteristics in hypermobile individuals with anxiety.Npj mental health research · 2026Article
- Idiopathic Scoliosis as a Conversion Reaction to Stress with the Neural Effect of a "Distorting Mirror".Life (Basel, Switzerland) · 2026Review
- Prevalence and management of mental health comorbidities in a German cohort of patients with Ehlers-Danlos syndromes and a generalized hypermobility spectrum disorder.Orphanet journal of rare diseases · 2026Article
- Neural processes linking joint hypermobility and anxiety: key roles for the amygdala and insular cortex.The British journal of psychiatry : the journal of mental science · 2026Article
- Exploring Transdiagnostic Eating Disorder Symptoms and Disorder of Gut-Brain Interaction Symptoms in Individuals With Connective Tissue Disorders.The International journal of eating disorders · 2026Article
- Modality-projection universal model for comprehensive full-body medical imaging segmentation.Nature communications · 2025Article
- Phenotyping Fatigue Profiles in Marfan Syndrome Through Cluster Analysis: A Cross-Sectional Study of Psychosocial and Clinical Correlates.Journal of clinical medicine · 2025Article
- Post-traumatic stress and joint hypermobility in children and adolescents of Nepal after exposure to an earthquake.European child & adolescent psychiatry · 2025Article
- Central Sensitivity Symptoms and Autistic Traits in Autistic and Non-Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2025Article
- A New Method to Evaluate Joint Hypermobility in Paediatric Patients with Neurodevelopmental Disorders: A Preliminary Study.Children (Basel, Switzerland) · 2024Article
- A model linking emotional dysregulation in neurodivergent people to the proprioceptive impact of joint hypermobility.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Is joint hypermobility linked to self-reported non-recovery from COVID-19? Case-control evidence from the British COVID Symptom Study Biobank.BMJ public health · 2024Article
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- Validation of the neuroconnective endophenotype questionnaire (NEQ): a new clinical tool for medicine and psychiatry resulting from the contribution of Ehlers-Danlos syndrome.Frontiers in medicine · 2023Article
- Article
- Overcoming barriers to autistic health care: towards autism-friendly practices.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- The Relationship Between Generalised Joint Hypermobility and Autism Spectrum Disorder in Adults: A Large, Cross-Sectional, Case Control Comparison.Frontiers in psychiatry · 2021Article
- Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The mind is embodied; thoughts and feelings interact with states of physiological arousal and physical integrity of the body. In this context, there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue, commonly recognised as joint hypermobility. Joint hypermobility is common, frequently under-recognised, significantly impacts quality of life, and can exist in isolation or as the hallmark of hypermobility spectrum disorders (encompassing joint hypermobility syndrome and hypermobile Ehlers-Danlos syndrome). In this narrative review, we appraise the current evidence linking psychiatric disorders across the lifespan, beginning with the relatively well-established connection with anxiety, to hypermobility. We next consider emerging associations with affective illnesses, eating disorders, alongside less well researched links with personality disorders, substance misuse and psychosis. We then review related findings relevant to neurodevelopmental disorders and stress-sensitive medical conditions. With growing understanding of mind-body interactions, we discuss potential aetiopathogenetic contributions of dysautonomia, aberrant interoceptive processing, immune dysregulation and proprioceptive impairments in the context of psychosocial stressors and genetic predisposition. We examine clinical implications of these evolving findings, calling for increased awareness amongst healthcare professionals of the transdiagnostic nature of hypermobility and related disorders. A role for early screening and detection of hypermobility in those presenting with mental health and somatic symptoms is further highlighted, with a view to facilitate preventative approaches alongside longer-term holistic management strategies. Finally, suggestions are offered for directions of future scientific exploration which may be key to further delineating fundamental mind-body-brain interactions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.