ArticleTranslational lung cancer research2021
Comparison of the efficiency of endobronchial ultrasound-guided transbronchial needle aspiration using a 22G needle versus 25G needle for the diagnosis of lymph node metastasis in patients with lung cancer: a prospective randomized, crossover study.
Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Cytology smears from endobronchial ultrasound-guided transbronchial needle aspiration as a source of nucleic acids with adequate yield for next-generation sequencing.Journal of thoracic disease · 2026Article
- Convex-probe endobronchial ultrasound-guided cryobiopsy for pleural tumors: three case reports.Translational lung cancer research · 2026Article
- Acquisition of endobronchial ultrasound bronchoscopy proficiency at a Canadian academic center.Journal of thoracic disease · 2026Article
- A case of malignant lymphoma with a peripheral pulmonary lesion diagnosed by endobronchial ultrasound-guided needle aspiration using a thin convex-probe endobronchial ultrasound bronchoscope.Respiratory medicine case reports · 2026Article
- Real-Life Comparison of Diagnostic Yield and Sample Adequacy of 22 G and 25 G EBUS-TBNB Needles: A Retrospective Study.Journal of clinical medicine · 2025Article
- Article
- Evolution of transbronchial needle aspiration needles: Over the last half century.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Predicting Malignant Lymph Nodes Using a Novel Scoring System Based on Multi-Endobronchial Ultrasound Features.Cancers · 2022Article
- Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): Technical Updates and Pathological Yield.Diagnostics (Basel, Switzerland) · 2021Review
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is generally performed for the diagnosis of hilar/mediastinal lymph node metastasis in patients with lung cancer. Recently, a 25-gauge (G) needle became available, but robust evidence of its usefulness in routine clinical practice is still lacking.
methodsA prospective randomized crossover trial was performed, in which patients with suspected hilar/mediastinal lymph node metastasis of lung cancer underwent EBUS-TBNA. The primary endpoint was the rate of yield histology specimens containing malignant cells.
resultsFrom December 2018 to February 2020, 102 patients were randomly assigned to EBUS-TBNA using a 22G needle first, followed by a 25G needle (n=50) or EBUS-TBNA using a 25G needle first, followed by a 22G needle (n=52). There was no difference in the diagnostic yield of malignancy between the histology specimens obtained by using the 22G and 25G needles (75%
conclusionsNo significant difference in the diagnostic yield between the 22G and 25G needles was observed for the diagnosis of lymph node metastasis of lung cancer, suggesting that needles of either gauge could be used for the biopsy. However, we would recommend use of the 22G needle, because it provided larger specimens and specimens containing larger numbers of malignant cells.
trial registrationUniversity hospital Medical Information Network Clinical Trial Registry (ID: UMIN000036680).
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