ReviewGastroenterology report2021
Role of gut microbiota in functional constipation.
Review in Gastroenterology report, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Pooled it
- Global research trajectories in gut microbiota and functional constipation: a bibliometric and visualization study.Frontiers in microbiology · 2024Pooled it
- A Heat-Inactivated Two-StrainNutrients · 2026Trial
- Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.Neurogastroenterology and motility · 2026Trial
- Trial
- Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype.World journal of gastroenterology · 2025Trial
- Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial.Scientific reports · 2024Trial
- Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Trial
- Article
- Kernel Fatty Oils ofNutrients · 2026Article
- AMarine drugs · 2026Article
- Prevalence and biopsychosocial associations of functional constipation: a cross-sectional study among adults in Türkiye.BMC gastroenterology · 2026Article
- Article
- Constipation prevalence and its association with kidney function: a large nationwide Japanese health check-up cohort study.Clinical kidney journal · 2026Article
- Associations of Autistic Traits and Autism with Incontinence and Constipation in a UK Birth Cohort.Journal of autism and developmental disorders · 2026Article
- Polydopamine cross-linked Bifidobacterium single cell core-shell system with multi-target regulation to alleviate constipation in mice.Archives of microbiology · 2026Article
- Cow's milk protein allergy in infants: Clinical presentations and outcomes.World journal of clinical pediatrics · 2026Article
- Probiotic-Driven Metabolic Transformation in Dark Tea: Enhanced Bioactives and Gut Microbiota Modulation Underlie Its Alleviation Effect Against Constipation.Foods (Basel, Switzerland) · 2026Article
- CFD protein deficiency induce slow transit constipation is correlated with gut microbial dysbiosis.Scientific reports · 2026Article
- Mechanisms of constipation alleviation by Lacticaseibacillus paracasei BGI-N2: insights from genes to phenotypes.BMC microbiology · 2026Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional constipation (FC) is common, yet the etiology is not clear. Accumulating evidence suggests an association between FC and abnormal gut microbiota. The relationship between the gut microbiota and the gut transit is likely bidirectional. This review summarizes the current evidence regarding the impact of gut microbiota on the pathogenesis of FC. By modulating the colonic motility, secretion, and absorption, gut microbiota may contribute to the development of FC through microbial metabolic activities involving bile acids, short-chain fatty acids, 5-hydroxytryptamine, and methane. In support of the key roles of the gut microbiota in FC, treatment with probiotics, prebiotics, synbiotics, and traditional Chinese medicine often result in compositional and functional changes in the gut microbiota. Further studies on the pathogenesis of FC and the therapeutic mechanism of microecological agents will provide a knowledge base for better management of FC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.