Evidence map›Paper›PMID 34733405›Full record

ArticleStatistical communications in infectious diseases2020

Challenges in evaluating the use of viral sequence data to identify HIV transmission networks for public health.

Rami Kantor, John P Fulton, Jon Steingrimsson, Vladimir Novitsky, Mark Howison, Fizza Gillani, Yuanning Li, Akarsh Manne, Zoanne Parillo, Matthew Spence and 7 more

Abstract read
In one paragraph

Article in Statistical communications in infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rami KantorBrown University, Providence, RI, USA.
John P FultonBrown University, Providence, RI, USA.
Jon SteingrimssonBrown University, Providence, RI, USA.
Vladimir NovitskyBrown University, Providence, RI, USA.
Mark HowisonResearch Improving People's Life, Providence, RI, USA.
Fizza GillaniBrown University, Providence, RI, USA.
Yuanning LiYale University, New Haven, CT, USA.
Akarsh ManneBrown University, Providence, RI, USA.
Zoanne ParilloRhode Island Department of Health, Providence, RI, USA.
Matthew SpenceRhode Island Department of Health, Providence, RI, USA.
Theodore MarakRhode Island Department of Health, Providence, RI, USA.
Philip ChanBrown University, Providence, RI, USA; Rhode Island Department of Health, Providence, RI, USA.
Casey W DunnYale University, New Haven, CT, USA.
Thomas BertrandRhode Island Department of Health, Providence, RI, USA.
Utpala BandyRhode Island Department of Health, Providence, RI, USA.
Nicole Alexander-ScottBrown University, Providence, RI, USA; Rhode Island Department of Health, Providence, RI, USA.
Joseph W HoganBrown University, Providence, RI, USA.

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Real Time Phylogeny and Contact Tracing to Disrupt HIV TransmissionR01AI136058 · NIAID · MIRIAM HOSPITAL · PI KANTOR, RAMI · 2018 to 2022
$3.4M
HIV Treatment Failure and Drug Resistance in Western Kenyan ChildrenR01AI120792 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KANTOR, RAMI, VREEMAN, RACHEL CHRISTINE · 2016 to 2019
$2.9M
Real Time Phylogeny and Contact Tracing to Disrupt HIV TransmissionR37AI136058 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2025 to 2026
$1.5M
HIV Drug Resistance, Monitoring and TransmissionK24AI134359 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2018 to 2026
$1.3M
NIAID NIH HHS K24 AI134359NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI120792NIAID NIH HHS R01 AI136058NIAID NIH HHS R37 AI136058
6 · The paper itself

Abstract

Great efforts are devoted to end the HIV epidemic as it continues to have profound public health consequences in the United States and throughout the world, and new interventions and strategies are continuously needed. The use of HIV sequence data to infer transmission networks holds much promise to direct public heath interventions where they are most needed. As these new methods are being implemented, evaluating their benefits is essential. In this paper, we recognize challenges associated with such evaluation, and make the case that overcoming these challenges is key to the use of HIV sequence data in routine public health actions to disrupt HIV transmission networks.

Indexed as

contact tracingHIVphylogenypublic health

Identifiers

PMID34733405
PMCPMC8561650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.